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Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study
OBJECTIVES: The association between habitual glucosamine use and incident gout has not been examined in previous studies. We aimed to evaluate the association of habitual use of glucosamine with the risk of gout in general population. METHODS: A total of 436,594 participants (55.4% female) without p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524004/ https://www.ncbi.nlm.nih.gov/pubmed/36175979 http://dx.doi.org/10.1186/s13293-022-00461-z |
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author | Liu, Mengyi Ye, Ziliang Zhang, Yanjun Yang, Sisi Wu, Qimeng Zhou, Chun He, Panpan Zhang, Yuanyuan Gan, Xiaoqin Qin, Xianhui |
author_facet | Liu, Mengyi Ye, Ziliang Zhang, Yanjun Yang, Sisi Wu, Qimeng Zhou, Chun He, Panpan Zhang, Yuanyuan Gan, Xiaoqin Qin, Xianhui |
author_sort | Liu, Mengyi |
collection | PubMed |
description | OBJECTIVES: The association between habitual glucosamine use and incident gout has not been examined in previous studies. We aimed to evaluate the association of habitual use of glucosamine with the risk of gout in general population. METHODS: A total of 436,594 participants (55.4% female) without prior gout at baseline who completed a questionnaire on supplementation use, which included glucosamine, in the UK Biobank were enrolled. Incident gout was recorded from self-report, death register, primary care, and hospital admission data. RESULTS: At baseline, 53,433 (22.1%) females and 30,685 (15.8%) males reported habitual glucosamine use. During a median follow-up period of 12.1 years, 1718 (0.7%) females and 5685 (2.9%) males developed gout. After multivariable adjustment for major risk factors, glucosamine use was associated with a significantly lower risk of incident gout in females (hazard ratio [HR], 0.81, 95% confidence interval [CI], 0.71–0.92), but not in males (HR, 1.05, 95% CI, 0.97–1.13), compared with non-use (P-interaction < 0.001). Among females, the inverse association between glucosamine use and gout was stronger in participants with diuretics use (HR, 0.64, 95% CI, 0.50–0.81) than those without diuretics use (HR, 0.89, 95% CI, 0.77–1.03) (P-interaction = 0.015). Moreover, gout genetic risk scores did not significantly modify the association between glucosamine use and the risk of incident gout in males (P-interaction = 0.548) or females (P-interaction = 0.183). CONCLUSIONS: Habitual glucosamine use to relieve osteoarthritis pain was related to lower risk of gout in females, but not in males. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13293-022-00461-z. |
format | Online Article Text |
id | pubmed-9524004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95240042022-10-01 Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study Liu, Mengyi Ye, Ziliang Zhang, Yanjun Yang, Sisi Wu, Qimeng Zhou, Chun He, Panpan Zhang, Yuanyuan Gan, Xiaoqin Qin, Xianhui Biol Sex Differ Research OBJECTIVES: The association between habitual glucosamine use and incident gout has not been examined in previous studies. We aimed to evaluate the association of habitual use of glucosamine with the risk of gout in general population. METHODS: A total of 436,594 participants (55.4% female) without prior gout at baseline who completed a questionnaire on supplementation use, which included glucosamine, in the UK Biobank were enrolled. Incident gout was recorded from self-report, death register, primary care, and hospital admission data. RESULTS: At baseline, 53,433 (22.1%) females and 30,685 (15.8%) males reported habitual glucosamine use. During a median follow-up period of 12.1 years, 1718 (0.7%) females and 5685 (2.9%) males developed gout. After multivariable adjustment for major risk factors, glucosamine use was associated with a significantly lower risk of incident gout in females (hazard ratio [HR], 0.81, 95% confidence interval [CI], 0.71–0.92), but not in males (HR, 1.05, 95% CI, 0.97–1.13), compared with non-use (P-interaction < 0.001). Among females, the inverse association between glucosamine use and gout was stronger in participants with diuretics use (HR, 0.64, 95% CI, 0.50–0.81) than those without diuretics use (HR, 0.89, 95% CI, 0.77–1.03) (P-interaction = 0.015). Moreover, gout genetic risk scores did not significantly modify the association between glucosamine use and the risk of incident gout in males (P-interaction = 0.548) or females (P-interaction = 0.183). CONCLUSIONS: Habitual glucosamine use to relieve osteoarthritis pain was related to lower risk of gout in females, but not in males. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13293-022-00461-z. BioMed Central 2022-09-30 /pmc/articles/PMC9524004/ /pubmed/36175979 http://dx.doi.org/10.1186/s13293-022-00461-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Liu, Mengyi Ye, Ziliang Zhang, Yanjun Yang, Sisi Wu, Qimeng Zhou, Chun He, Panpan Zhang, Yuanyuan Gan, Xiaoqin Qin, Xianhui Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
title | Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
title_full | Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
title_fullStr | Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
title_full_unstemmed | Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
title_short | Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
title_sort | associations of habitual glucosamine supplementation with incident gout: a large population based cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524004/ https://www.ncbi.nlm.nih.gov/pubmed/36175979 http://dx.doi.org/10.1186/s13293-022-00461-z |
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