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Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques

BACKGROUND: Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. Since ASSRs are disturbed in human psychiatric disorders, recording ASSRs from...

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Autores principales: Nakamura, Tomoya, Dinh, Trong Ha, Asai, Makoto, Nishimaru, Hiroshi, Matsumoto, Jumpei, Setogawa, Tsuyoshi, Ichijo, Hiroyuki, Honda, Sokichi, Yamada, Hiroshi, Mihara, Takuma, Nishijo, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524006/
https://www.ncbi.nlm.nih.gov/pubmed/36180823
http://dx.doi.org/10.1186/s12868-022-00741-9
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author Nakamura, Tomoya
Dinh, Trong Ha
Asai, Makoto
Nishimaru, Hiroshi
Matsumoto, Jumpei
Setogawa, Tsuyoshi
Ichijo, Hiroyuki
Honda, Sokichi
Yamada, Hiroshi
Mihara, Takuma
Nishijo, Hisao
author_facet Nakamura, Tomoya
Dinh, Trong Ha
Asai, Makoto
Nishimaru, Hiroshi
Matsumoto, Jumpei
Setogawa, Tsuyoshi
Ichijo, Hiroyuki
Honda, Sokichi
Yamada, Hiroshi
Mihara, Takuma
Nishijo, Hisao
author_sort Nakamura, Tomoya
collection PubMed
description BACKGROUND: Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. Since ASSRs are disturbed in human psychiatric disorders, recording ASSRs from awake intact macaques would be beneficial to translational research as well as an understanding of human brain function and its pathology. However, ASSR has not been reported in awake macaques. RESULTS: Electroencephalograms (EEGs) were recorded from awake intact macaques, while click trains at 20–83.3 Hz were binaurally presented. EEGs were quantified based on event-related spectral perturbation (ERSP) and inter-trial coherence (ITC), and ASSRs were significantly demonstrated in terms of ERSP and ITC in awake intact macaques. A comparison of ASSRs among different click train frequencies indicated that ASSRs were maximal at 83.3 Hz. Furthermore, analyses of laterality indices of ASSRs showed that no laterality dominance of ASSRs was observed. CONCLUSIONS: The present results demonstrated ASSRs, comparable to those in humans, in awake intact macaques. However, there were some differences in ASSRs between macaques and humans: macaques showed maximal ASSR responses to click frequencies higher than 40 Hz that has been reported to elicit maximal responses in humans, and showed no dominant laterality of ASSRs under the electrode montage in this study compared with humans with right hemisphere dominance. The future ASSR studies using awake intact macaques should be aware of these differences, and possible factors, to which these differences were ascribed, are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12868-022-00741-9.
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spelling pubmed-95240062022-10-01 Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques Nakamura, Tomoya Dinh, Trong Ha Asai, Makoto Nishimaru, Hiroshi Matsumoto, Jumpei Setogawa, Tsuyoshi Ichijo, Hiroyuki Honda, Sokichi Yamada, Hiroshi Mihara, Takuma Nishijo, Hisao BMC Neurosci Research BACKGROUND: Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. Since ASSRs are disturbed in human psychiatric disorders, recording ASSRs from awake intact macaques would be beneficial to translational research as well as an understanding of human brain function and its pathology. However, ASSR has not been reported in awake macaques. RESULTS: Electroencephalograms (EEGs) were recorded from awake intact macaques, while click trains at 20–83.3 Hz were binaurally presented. EEGs were quantified based on event-related spectral perturbation (ERSP) and inter-trial coherence (ITC), and ASSRs were significantly demonstrated in terms of ERSP and ITC in awake intact macaques. A comparison of ASSRs among different click train frequencies indicated that ASSRs were maximal at 83.3 Hz. Furthermore, analyses of laterality indices of ASSRs showed that no laterality dominance of ASSRs was observed. CONCLUSIONS: The present results demonstrated ASSRs, comparable to those in humans, in awake intact macaques. However, there were some differences in ASSRs between macaques and humans: macaques showed maximal ASSR responses to click frequencies higher than 40 Hz that has been reported to elicit maximal responses in humans, and showed no dominant laterality of ASSRs under the electrode montage in this study compared with humans with right hemisphere dominance. The future ASSR studies using awake intact macaques should be aware of these differences, and possible factors, to which these differences were ascribed, are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12868-022-00741-9. BioMed Central 2022-09-30 /pmc/articles/PMC9524006/ /pubmed/36180823 http://dx.doi.org/10.1186/s12868-022-00741-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Nakamura, Tomoya
Dinh, Trong Ha
Asai, Makoto
Nishimaru, Hiroshi
Matsumoto, Jumpei
Setogawa, Tsuyoshi
Ichijo, Hiroyuki
Honda, Sokichi
Yamada, Hiroshi
Mihara, Takuma
Nishijo, Hisao
Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
title Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
title_full Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
title_fullStr Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
title_full_unstemmed Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
title_short Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
title_sort characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524006/
https://www.ncbi.nlm.nih.gov/pubmed/36180823
http://dx.doi.org/10.1186/s12868-022-00741-9
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