Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins

BACKGROUND: Akt and mTOR are aberrantly activated in cancers and targeting these proteins are interesting for cancer drug discovery. Napabucasin (NB), a phytochemical compound, has been reported as potential anti-cancer agent, however, Akt and mTOR targeting mechanisms remain unclear.  METHOD: Apopt...

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Detalles Bibliográficos
Autores principales: Petsri, Korrakod, Thongsom, Sunisa, Racha, Satapat, Chamni, Supakarn, Jindapol, Saresa, Kaekratoke, Nantawat, Zou, Hongbin, Chanvorachote, Pithi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524025/
https://www.ncbi.nlm.nih.gov/pubmed/36180880
http://dx.doi.org/10.1186/s12906-022-03727-6

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