Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease

BACKGROUND: Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are compromised in Alzheimer’s disease (AD). Ex vivo expansion of...

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Detalles Bibliográficos
Autores principales: Faridar, Alireza, Vasquez, Matthew, Thome, Aaron D., Yin, Zheng, Xuan, Hui, Wang, Jing Hong, Wen, Shixiang, Li, Xuping, Thonhoff, Jason R., Zhao, Weihua, Zhao, Hong, Beers, David R., Wong, Stephen T. C., Masdeu, Joseph C., Appel, Stanley H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524037/
https://www.ncbi.nlm.nih.gov/pubmed/36180898
http://dx.doi.org/10.1186/s40478-022-01447-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524037/
https://www.ncbi.nlm.nih.gov/pubmed/36180898
http://dx.doi.org/10.1186/s40478-022-01447-z

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