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Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

OBJECTIVE: This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning. METHODS: A systematic search of PubMed, EMBASE, and the Web of Science for observational studies published up until the 6(...

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Autores principales: Cai, Wang-Yu, Luo, Xi, Wu, Wei, Song, Jianyuan, Xie, Ning-Ning, Duan, Cuicui, Wu, Xiao-Ke, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524128/
https://www.ncbi.nlm.nih.gov/pubmed/36180908
http://dx.doi.org/10.1186/s13048-022-01041-w
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author Cai, Wang-Yu
Luo, Xi
Wu, Wei
Song, Jianyuan
Xie, Ning-Ning
Duan, Cuicui
Wu, Xiao-Ke
Xu, Jian
author_facet Cai, Wang-Yu
Luo, Xi
Wu, Wei
Song, Jianyuan
Xie, Ning-Ning
Duan, Cuicui
Wu, Xiao-Ke
Xu, Jian
author_sort Cai, Wang-Yu
collection PubMed
description OBJECTIVE: This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning. METHODS: A systematic search of PubMed, EMBASE, and the Web of Science for observational studies published up until the 6(th) of July 2021 that compared the metabolic profile of POI women with a healthy control group were assessed. Mean differences (MD) and 95% confidence interval (CI) were pooled using the fixed or random effect models. RESULTS: A total of 21 studies involving 1573 women with POI and 1762 control women were included. POI patients presented significantly higher waist circumference, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, and fasting glucose. Additionally, POI patients had marginally higher insulin level. However, the differences in systolic, and diastolic blood pressure were non-significant relative to the control group. CONCLUSIONS: POI is associated with alterations in certain metabolic parameters compared to control women. This finding highlights the importance of early screening and the lifelong management of metabolic health for women with POI. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13048-022-01041-w.
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spelling pubmed-95241282022-10-01 Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis Cai, Wang-Yu Luo, Xi Wu, Wei Song, Jianyuan Xie, Ning-Ning Duan, Cuicui Wu, Xiao-Ke Xu, Jian J Ovarian Res Review OBJECTIVE: This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning. METHODS: A systematic search of PubMed, EMBASE, and the Web of Science for observational studies published up until the 6(th) of July 2021 that compared the metabolic profile of POI women with a healthy control group were assessed. Mean differences (MD) and 95% confidence interval (CI) were pooled using the fixed or random effect models. RESULTS: A total of 21 studies involving 1573 women with POI and 1762 control women were included. POI patients presented significantly higher waist circumference, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, and fasting glucose. Additionally, POI patients had marginally higher insulin level. However, the differences in systolic, and diastolic blood pressure were non-significant relative to the control group. CONCLUSIONS: POI is associated with alterations in certain metabolic parameters compared to control women. This finding highlights the importance of early screening and the lifelong management of metabolic health for women with POI. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13048-022-01041-w. BioMed Central 2022-09-30 /pmc/articles/PMC9524128/ /pubmed/36180908 http://dx.doi.org/10.1186/s13048-022-01041-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Cai, Wang-Yu
Luo, Xi
Wu, Wei
Song, Jianyuan
Xie, Ning-Ning
Duan, Cuicui
Wu, Xiao-Ke
Xu, Jian
Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
title Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
title_full Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
title_fullStr Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
title_full_unstemmed Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
title_short Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
title_sort metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524128/
https://www.ncbi.nlm.nih.gov/pubmed/36180908
http://dx.doi.org/10.1186/s13048-022-01041-w
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