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New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival

Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting and degrading aging proteins and damaged organelles. The effect of autophagy on neural tissue is still a matter of debate. Some authors suggest that autophagy has a protective effect on nerve cells, whereas ot...

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Autores principales: Gao, Yahao, Wang, Changshui, Jiang, Di, An, Gang, Jin, Feng, Zhang, Junchen, Han, Guangkui, Cui, Changmeng, Jiang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524158/
https://www.ncbi.nlm.nih.gov/pubmed/36187470
http://dx.doi.org/10.3389/fcell.2022.994037
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author Gao, Yahao
Wang, Changshui
Jiang, Di
An, Gang
Jin, Feng
Zhang, Junchen
Han, Guangkui
Cui, Changmeng
Jiang, Pei
author_facet Gao, Yahao
Wang, Changshui
Jiang, Di
An, Gang
Jin, Feng
Zhang, Junchen
Han, Guangkui
Cui, Changmeng
Jiang, Pei
author_sort Gao, Yahao
collection PubMed
description Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting and degrading aging proteins and damaged organelles. The effect of autophagy on neural tissue is still a matter of debate. Some authors suggest that autophagy has a protective effect on nerve cells, whereas others suggest that autophagy also induces the death of nerve cells and aggravates nerve injury. In mammals, oxidative stress, autophagy and endoplasmic reticulum stress (ERS) constitute important defense mechanisms to help cells adapt to and survive the stress conditions caused by physiological and pathological stimuli. Under many pathophysiological conditions, oxidative stress, autophagy and ERS are integrated and amplified in cells to promote the progress of diseases. Over the past few decades, oxidative stress, autophagy and ERS and their interactions have been a hot topic in biomedical research. In this review, we summarize recent advances in understanding the interactions between oxidative stress, autophagy and ERS in neuronal cell death and survival.
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spelling pubmed-95241582022-10-01 New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival Gao, Yahao Wang, Changshui Jiang, Di An, Gang Jin, Feng Zhang, Junchen Han, Guangkui Cui, Changmeng Jiang, Pei Front Cell Dev Biol Cell and Developmental Biology Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting and degrading aging proteins and damaged organelles. The effect of autophagy on neural tissue is still a matter of debate. Some authors suggest that autophagy has a protective effect on nerve cells, whereas others suggest that autophagy also induces the death of nerve cells and aggravates nerve injury. In mammals, oxidative stress, autophagy and endoplasmic reticulum stress (ERS) constitute important defense mechanisms to help cells adapt to and survive the stress conditions caused by physiological and pathological stimuli. Under many pathophysiological conditions, oxidative stress, autophagy and ERS are integrated and amplified in cells to promote the progress of diseases. Over the past few decades, oxidative stress, autophagy and ERS and their interactions have been a hot topic in biomedical research. In this review, we summarize recent advances in understanding the interactions between oxidative stress, autophagy and ERS in neuronal cell death and survival. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9524158/ /pubmed/36187470 http://dx.doi.org/10.3389/fcell.2022.994037 Text en Copyright © 2022 Gao, Wang, Jiang, An, Jin, Zhang, Han, Cui and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Gao, Yahao
Wang, Changshui
Jiang, Di
An, Gang
Jin, Feng
Zhang, Junchen
Han, Guangkui
Cui, Changmeng
Jiang, Pei
New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
title New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
title_full New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
title_fullStr New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
title_full_unstemmed New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
title_short New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
title_sort new insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524158/
https://www.ncbi.nlm.nih.gov/pubmed/36187470
http://dx.doi.org/10.3389/fcell.2022.994037
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