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Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine
In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524231/ https://www.ncbi.nlm.nih.gov/pubmed/36185233 http://dx.doi.org/10.3389/fonc.2022.956923 |
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author | Fraile-Martinez, Oscar Alvarez-Mon, Miguel A. Garcia-Montero, Cielo Pekarek, Leonel Guijarro, Luis G. Lahera, Guillermo Saez, Miguel A. Monserrat, Jorge Motogo, Domitila Quintero, Javier Alvarez-Mon, Melchor Ortega, Miguel A. |
author_facet | Fraile-Martinez, Oscar Alvarez-Mon, Miguel A. Garcia-Montero, Cielo Pekarek, Leonel Guijarro, Luis G. Lahera, Guillermo Saez, Miguel A. Monserrat, Jorge Motogo, Domitila Quintero, Javier Alvarez-Mon, Melchor Ortega, Miguel A. |
author_sort | Fraile-Martinez, Oscar |
collection | PubMed |
description | In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, added to the diagnosis of the disease itself, cause an increase in the incidence of depressive disorders. These alterations have important consequences for the patients, reducing their average survival and quality of life, and for these reasons, special emphasis has been placed on developing numerous screening tests and early recognition of depressive symptoms. Despite that cancer and major depressive disorder are complex and heterogeneous entities, they also share many critical pathophysiological mechanisms, aiding to explain this complex relationship from a biological perspective. Moreover, a growing body of evidence is supporting the relevant role of lifestyle habits in the prevention and management of both depression and cancer. Therefore, the present study aims to perform a thorough review of the intricate relationship between depression and cancer, with a special focus on its biological links, clinical management, challenges, and the central role of lifestyle medicine as adjunctive and preventive approaches to improve the quality of life of these patients. |
format | Online Article Text |
id | pubmed-9524231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95242312022-10-01 Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine Fraile-Martinez, Oscar Alvarez-Mon, Miguel A. Garcia-Montero, Cielo Pekarek, Leonel Guijarro, Luis G. Lahera, Guillermo Saez, Miguel A. Monserrat, Jorge Motogo, Domitila Quintero, Javier Alvarez-Mon, Melchor Ortega, Miguel A. Front Oncol Oncology In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, added to the diagnosis of the disease itself, cause an increase in the incidence of depressive disorders. These alterations have important consequences for the patients, reducing their average survival and quality of life, and for these reasons, special emphasis has been placed on developing numerous screening tests and early recognition of depressive symptoms. Despite that cancer and major depressive disorder are complex and heterogeneous entities, they also share many critical pathophysiological mechanisms, aiding to explain this complex relationship from a biological perspective. Moreover, a growing body of evidence is supporting the relevant role of lifestyle habits in the prevention and management of both depression and cancer. Therefore, the present study aims to perform a thorough review of the intricate relationship between depression and cancer, with a special focus on its biological links, clinical management, challenges, and the central role of lifestyle medicine as adjunctive and preventive approaches to improve the quality of life of these patients. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9524231/ /pubmed/36185233 http://dx.doi.org/10.3389/fonc.2022.956923 Text en Copyright © 2022 Fraile-Martinez, Alvarez-Mon, Garcia-Montero, Pekarek, Guijarro, Lahera, Saez, Monserrat, Motogo, Quintero, Alvarez-Mon and Ortega https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fraile-Martinez, Oscar Alvarez-Mon, Miguel A. Garcia-Montero, Cielo Pekarek, Leonel Guijarro, Luis G. Lahera, Guillermo Saez, Miguel A. Monserrat, Jorge Motogo, Domitila Quintero, Javier Alvarez-Mon, Melchor Ortega, Miguel A. Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
title | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
title_full | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
title_fullStr | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
title_full_unstemmed | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
title_short | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
title_sort | understanding the basis of major depressive disorder in oncological patients: biological links, clinical management, challenges, and lifestyle medicine |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524231/ https://www.ncbi.nlm.nih.gov/pubmed/36185233 http://dx.doi.org/10.3389/fonc.2022.956923 |
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