Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody library

The COVID−19 pandemic not only resulted in a global crisis, but also accelerated vaccine development and antibody discovery. Herein we report a synthetic humanized VHH library development pipeline for nanomolar-range affinity VHH binders to SARS-CoV-2 variants of concern (VoC) receptor binding domai...

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Detalles Bibliográficos
Autores principales: Dormeshkin, Dmitri, Shapira, Michail, Dubovik, Simon, Kavaleuski, Anton, Katsin, Mikalai, Migas, Alexandr, Meleshko, Alexander, Semyonov, Sergei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524272/
https://www.ncbi.nlm.nih.gov/pubmed/36189235
http://dx.doi.org/10.3389/fimmu.2022.965446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524272/
https://www.ncbi.nlm.nih.gov/pubmed/36189235
http://dx.doi.org/10.3389/fimmu.2022.965446

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