Cargando…

Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody library

The COVID−19 pandemic not only resulted in a global crisis, but also accelerated vaccine development and antibody discovery. Herein we report a synthetic humanized VHH library development pipeline for nanomolar-range affinity VHH binders to SARS-CoV-2 variants of concern (VoC) receptor binding domai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dormeshkin, Dmitri, Shapira, Michail, Dubovik, Simon, Kavaleuski, Anton, Katsin, Mikalai, Migas, Alexandr, Meleshko, Alexander, Semyonov, Sergei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524272/ https://www.ncbi.nlm.nih.gov/pubmed/36189235 http://dx.doi.org/10.3389/fimmu.2022.965446

Ejemplares similares

Design and Immunogenicity of SARS-CoV-2 DNA Vaccine Encoding RBD-PVXCP Fusion Protein
por: Dormeshkin, Dmitri, et al.
Publicado: (2023)

CAR-T Cell Therapy for Classical Hodgkin Lymphoma
por: Katsin, Mikalai, et al.
Publicado: (2023)

Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex
por: Desmyter, Aline, et al.
Publicado: (2017)

Selecting Nanobodies Specific for the Epidermal Growth Factor from a Synthetic Nanobody Library
por: Serrano-Rivero, Yunier, et al.
Publicado: (2023)

Structural Insights into the Design of Synthetic Nanobody Libraries
por: Valdés-Tresanco, Mario S., et al.
Publicado: (2022)

Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study
por: Meleshko, Alexander, et al.
Publicado: (2022)

Nanobodies—Useful Tools for Allergy Treatment?
por: Flicker, Sabine, et al.
Publicado: (2020)

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics
por: Bannas, Peter, et al.
Publicado: (2017)

Nanobodies that Neutralize HIV
por: Weiss, Robin A., et al.
Publicado: (2019)

Prospects of Neutralizing Nanobodies Against SARS-CoV-2
por: Chen, Fangfang, et al.
Publicado: (2021)

Easily Established and Multifunctional Synthetic Nanobody Libraries as Research Tools
por: Liu, Bingying, et al.
Publicado: (2022)

Immunogenicity Risk Profile of Nanobodies
por: Ackaert, Chloé, et al.
Publicado: (2021)

Applications of nanobodies in brain diseases
por: Zheng, Fang, et al.
Publicado: (2022)

Structure-based design and construction of a synthetic phage display nanobody library
por: Moreno, Ernesto, et al.
Publicado: (2022)

Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
por: Stefan, Maxwell A., et al.
Publicado: (2021)

Development and Characterization of Nanobodies Targeting the Kupffer Cell
por: Zheng, Fang, et al.
Publicado: (2021)

Editorial: Nanobody-based cancer immunotherapy and immunoimaging
por: Jafari, Mahdie, et al.
Publicado: (2023)

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
por: Schoof, Michael, et al.
Publicado: (2020)

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
por: Custódio, Tânia F., et al.
Publicado: (2020)

Recombinant expression of nanobodies and nanobody-derived immunoreagents
por: de Marco, Ario
Publicado: (2020)

Generation of Synthetic Acinetobacter baumannii-Specific Nanobodies
por: Knauf, Gregory A., et al.
Publicado: (2023)

Nanobodies: Prospects of Expanding the Gamut of Neutralizing Antibodies Against the Novel Coronavirus, SARS-CoV-2
por: Konwarh, Rocktotpal
Publicado: (2020)

Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers
por: Arezumand, Roghaye, et al.
Publicado: (2017)

Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis
por: Stijlemans, Benoit, et al.
Publicado: (2017)

Nanobodies in cell-mediated immunotherapy: On the road to fight cancer
por: Maali, Amirhosein, et al.
Publicado: (2023)

Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis
por: Zupancic, Jennifer M., et al.
Publicado: (2022)

Characterization and applications of Nanobodies against human procalcitonin selected from a novel naïve Nanobody phage display library
por: Yan, Junrong, et al.
Publicado: (2015)

A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
por: Chen, Xun, et al.
Publicado: (2021)

Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors
por: Hambach, Julia, et al.
Publicado: (2022)

CAMEL NANOBODIES NEUTRALIZE SARS-COV-2 VARIANTS
por: Hong, Jessica, et al.
Publicado: (2023)

Nanobody-Based Delivery Systems for Diagnosis and Targeted Tumor Therapy
por: Hu, Yaozhong, et al.
Publicado: (2017)

Construction of a T7 phage display nanobody library for bio-panning and identification of chicken dendritic cell-specific binding nanobodies
por: Xu, Hai, et al.
Publicado: (2022)

Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data
por: Deschaght, Pieter, et al.
Publicado: (2017)

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
por: Schoof, Michael, et al.
Publicado: (2020)

Generation of high affinity ICAM-1-specific nanobodies and evaluation of their suitability for allergy treatment
por: Zettl, Ines, et al.
Publicado: (2022)

Research Progress and Applications of Multivalent, Multispecific and Modified Nanobodies for Disease Treatment
por: Wang, Jiewen, et al.
Publicado: (2022)

Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions
por: Schriek, Angela I., et al.
Publicado: (2022)

Design and Construction of a Synthetic Nanobody Library: Testing Its Potential with a Single Selection Round Strategy
por: Contreras, María Angélica, et al.
Publicado: (2023)

Synthetic nanobodies as tools to distinguish IgG Fc glycoforms
por: Kao, Kevin S., et al.
Publicado: (2022)

An improved yeast surface display platform for the screening of nanobody immune libraries
por: Uchański, Tomasz, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t9g7c5fbgfihn5h7jn24d02gk7