Cargando…

Calcifying fibrous tumor

Calcifying fibrous tumor is a rare benign mesenchymal neoplasm. The etiology and pathogenesis of this tumor are uncertain. It has wide anatomical distribution. The tumor is most commonly found in the soft tissues of the extremities in younger individuals. However, in middle-aged patients, it tends t...

Descripción completa

Detalles Bibliográficos
Autores principales: Elsarraj, Hanan, Hamza, Ameer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital Universitário da Universidade de São Paulo 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524383/
https://www.ncbi.nlm.nih.gov/pubmed/36186113
http://dx.doi.org/10.4322/acr.2021.400
_version_ 1784800496335192064
author Elsarraj, Hanan
Hamza, Ameer
author_facet Elsarraj, Hanan
Hamza, Ameer
author_sort Elsarraj, Hanan
collection PubMed
description Calcifying fibrous tumor is a rare benign mesenchymal neoplasm. The etiology and pathogenesis of this tumor are uncertain. It has wide anatomical distribution. The tumor is most commonly found in the soft tissues of the extremities in younger individuals. However, in middle-aged patients, it tends to affect the visceral locations more commonly. In visceral location, it can mimic aggressive lesions clinically. The purpose of this report is to describe a case of calcifying fibrous tumor in a 71-year-old female with a history of breast carcinoma who was found to have an incidental small bowel mass on her follow-up. Clinically and radiologically, the mass was suspicious for either metastatic disease or gastrointestinal stromal tumor. The patient underwent open small bowel resection, and a 6.5 cm segment of the small bowel was sent to pathology. Grossly, a 2.0 cm tan-pink smooth round submucosal polyploid mass protruding into the lumen, mimicking a gastrointestinal stromal tumor, was identified. The tumor was hard and serially sectioned to reveal a white, calcified cut surface. Microscopically, the tumor appeared hypocellular and composed of scant spindle cells embedded in a dense, hyalinized and calcified collagenous stroma. Immunohistochemical stains for pan-cytokeratin, DOG1, desmin, S100, CD34, and MUC4 were negative, and a diagnosis of the calcifying fibrous tumor was rendered. This case provides a rare gross specimen image of calcifying fibrous tumor and highlights the importance of knowledge of rare entities in providing an accurate diagnosis for entities that can mimic other lesions.
format Online
Article
Text
id pubmed-9524383
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hospital Universitário da Universidade de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-95243832022-10-01 Calcifying fibrous tumor Elsarraj, Hanan Hamza, Ameer Autops Case Rep Clinical Case Report Calcifying fibrous tumor is a rare benign mesenchymal neoplasm. The etiology and pathogenesis of this tumor are uncertain. It has wide anatomical distribution. The tumor is most commonly found in the soft tissues of the extremities in younger individuals. However, in middle-aged patients, it tends to affect the visceral locations more commonly. In visceral location, it can mimic aggressive lesions clinically. The purpose of this report is to describe a case of calcifying fibrous tumor in a 71-year-old female with a history of breast carcinoma who was found to have an incidental small bowel mass on her follow-up. Clinically and radiologically, the mass was suspicious for either metastatic disease or gastrointestinal stromal tumor. The patient underwent open small bowel resection, and a 6.5 cm segment of the small bowel was sent to pathology. Grossly, a 2.0 cm tan-pink smooth round submucosal polyploid mass protruding into the lumen, mimicking a gastrointestinal stromal tumor, was identified. The tumor was hard and serially sectioned to reveal a white, calcified cut surface. Microscopically, the tumor appeared hypocellular and composed of scant spindle cells embedded in a dense, hyalinized and calcified collagenous stroma. Immunohistochemical stains for pan-cytokeratin, DOG1, desmin, S100, CD34, and MUC4 were negative, and a diagnosis of the calcifying fibrous tumor was rendered. This case provides a rare gross specimen image of calcifying fibrous tumor and highlights the importance of knowledge of rare entities in providing an accurate diagnosis for entities that can mimic other lesions. Hospital Universitário da Universidade de São Paulo 2022-09-20 /pmc/articles/PMC9524383/ /pubmed/36186113 http://dx.doi.org/10.4322/acr.2021.400 Text en Copyright © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Case Report
Elsarraj, Hanan
Hamza, Ameer
Calcifying fibrous tumor
title Calcifying fibrous tumor
title_full Calcifying fibrous tumor
title_fullStr Calcifying fibrous tumor
title_full_unstemmed Calcifying fibrous tumor
title_short Calcifying fibrous tumor
title_sort calcifying fibrous tumor
topic Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524383/
https://www.ncbi.nlm.nih.gov/pubmed/36186113
http://dx.doi.org/10.4322/acr.2021.400
work_keys_str_mv AT elsarrajhanan calcifyingfibroustumor
AT hamzaameer calcifyingfibroustumor