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Neurofibromatosis Type I and Hodgkin Lymphoma: Case Report and Review of the Literature

OBJECTIVE: Neurofibromatosis 1 is an autosomal dominant inherited tumor susceptibility syndrome. Individuals with neurofibromatosis 1 have a 4-5 times increased risk of malignancy compared to the general population. Central nervous system and soft tissue tumors are common non-hematological malignanc...

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Detalles Bibliográficos
Autores principales: Yıldırım, Ülkü Miray, Kebudi, Rejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Pediatrics Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524435/
https://www.ncbi.nlm.nih.gov/pubmed/36062445
http://dx.doi.org/10.5152/TurkArchPediatr.2022.22004
Descripción
Sumario:OBJECTIVE: Neurofibromatosis 1 is an autosomal dominant inherited tumor susceptibility syndrome. Individuals with neurofibromatosis 1 have a 4-5 times increased risk of malignancy compared to the general population. Central nervous system and soft tissue tumors are common non-hematological malignancies in individuals with neurofibromatosis 1. Although the association of leukemia and non-Hodgkin lymphoma as hematologic malignancies in neurofibromatosis 1 has been reported frequently in the literature in these individuals, association with Hodgkin lymphoma has been reported very rarely. MATERIALS AND METHODS: We presented a patient with neurofibromatosis 1 who further developed Hodgkin lymphoma and reviewed the literature. CONCLUSION: Although rare, Hodgkin lymphoma can develop in individuals with neurofibromatosis 1. Hodgkin lymphoma should be kept in mind in cervical/supraclavicular lymphadenomegalies when evaluating patients with neurofibromatosis 1.