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Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study

BACKGROUND: Long noncoding RNAs increase the overexpression of oncogenes. Cancer development and metastasis of cancer may occur as a result of overexpression of oncogenes. Polymorphisms in the genes (such as HOTAIR, etc.) in which long noncoding RNAs are synthesized affect the expression of these ge...

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Autores principales: Yalınbaş Kaya, Berrin, Peker, Betül, Tuğrul, Fuzuli, Alkan Tali, Özge, Bayram, Süleyman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524440/
https://www.ncbi.nlm.nih.gov/pubmed/35946893
http://dx.doi.org/10.5152/tjg.2022.21836
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author Yalınbaş Kaya, Berrin
Peker, Betül
Tuğrul, Fuzuli
Alkan Tali, Özge
Bayram, Süleyman
author_facet Yalınbaş Kaya, Berrin
Peker, Betül
Tuğrul, Fuzuli
Alkan Tali, Özge
Bayram, Süleyman
author_sort Yalınbaş Kaya, Berrin
collection PubMed
description BACKGROUND: Long noncoding RNAs increase the overexpression of oncogenes. Cancer development and metastasis of cancer may occur as a result of overexpression of oncogenes. Polymorphisms in the genes (such as HOTAIR, etc.) in which long noncoding RNAs are synthesized affect the expression of these genes. Therefore, these polymorphisms may play a role in cancer development and cancer metastasis. The present study aimed to evaluate the association between HOTAIR gene rs1899663 G>T polymorphism with colorectal cancer. METHODS: The current study examined the HOTAIR gene rs1899663 G>T polymorphism in 100 patients with colorectal cancer and 93 healthy persons by a real-time polymerase chain reaction. RESULTS: The G and T allele frequencies of the HOTAIR rs1899663 polymorphism were significantly different between the case and control groups (P = .01). The persons carrying the G allele had a protective effect against colorectal cancer, while individuals carrying the T allele were predisposed to colorectal cancer (P = .001). Four of 5 colorectal cancer recurrence patients had the TT genotype (P = .02). CONCLUSION: This research is the first to demonstrate the relationship between colorectal cancer and the HOTAIR gene rs1899663 polymorphism in the Turkish population, which is a Caucasian population. Our results suggest that the rs1899663 G allele has a protective role for colorectal cancer in the Turkish population. However, it would be appropriate to conduct this research with a larger sample to confirm this result in the Turkish population.
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spelling pubmed-95244402022-10-13 Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study Yalınbaş Kaya, Berrin Peker, Betül Tuğrul, Fuzuli Alkan Tali, Özge Bayram, Süleyman Turk J Gastroenterol Original Article BACKGROUND: Long noncoding RNAs increase the overexpression of oncogenes. Cancer development and metastasis of cancer may occur as a result of overexpression of oncogenes. Polymorphisms in the genes (such as HOTAIR, etc.) in which long noncoding RNAs are synthesized affect the expression of these genes. Therefore, these polymorphisms may play a role in cancer development and cancer metastasis. The present study aimed to evaluate the association between HOTAIR gene rs1899663 G>T polymorphism with colorectal cancer. METHODS: The current study examined the HOTAIR gene rs1899663 G>T polymorphism in 100 patients with colorectal cancer and 93 healthy persons by a real-time polymerase chain reaction. RESULTS: The G and T allele frequencies of the HOTAIR rs1899663 polymorphism were significantly different between the case and control groups (P = .01). The persons carrying the G allele had a protective effect against colorectal cancer, while individuals carrying the T allele were predisposed to colorectal cancer (P = .001). Four of 5 colorectal cancer recurrence patients had the TT genotype (P = .02). CONCLUSION: This research is the first to demonstrate the relationship between colorectal cancer and the HOTAIR gene rs1899663 polymorphism in the Turkish population, which is a Caucasian population. Our results suggest that the rs1899663 G allele has a protective role for colorectal cancer in the Turkish population. However, it would be appropriate to conduct this research with a larger sample to confirm this result in the Turkish population. Turkish Society of Gastroenterology 2022-08-01 /pmc/articles/PMC9524440/ /pubmed/35946893 http://dx.doi.org/10.5152/tjg.2022.21836 Text en © Copyright 2022 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Yalınbaş Kaya, Berrin
Peker, Betül
Tuğrul, Fuzuli
Alkan Tali, Özge
Bayram, Süleyman
Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study
title Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study
title_full Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study
title_fullStr Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study
title_full_unstemmed Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study
title_short Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study
title_sort association of hotair rs1899663 g>t polymorphism with colorectal cancer in the turkish population: a case–control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524440/
https://www.ncbi.nlm.nih.gov/pubmed/35946893
http://dx.doi.org/10.5152/tjg.2022.21836
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