Cargando…
Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies
BACKGROUND: We aimed to determine the clinical features, predictive factors associated with severe disease, and outcomes of coronavirus disease 2019 in patients with immune-mediated inflammatory diseases and report data on the comparison of coronavirus disease 2019 between patients with inflammatory...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Turkish Society of Gastroenterology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524500/ https://www.ncbi.nlm.nih.gov/pubmed/36134550 http://dx.doi.org/10.5152/tjg.2022.22181 |
_version_ | 1784800520334999552 |
---|---|
author | Tozlu, Mukaddes Dilek, Gamze Kalçık Unan, Mehtap Kamanlı, Ayhan Tekeoğlu, İbrahim Uslan, Mustafa İhsan Nas, Kemal |
author_facet | Tozlu, Mukaddes Dilek, Gamze Kalçık Unan, Mehtap Kamanlı, Ayhan Tekeoğlu, İbrahim Uslan, Mustafa İhsan Nas, Kemal |
author_sort | Tozlu, Mukaddes |
collection | PubMed |
description | BACKGROUND: We aimed to determine the clinical features, predictive factors associated with severe disease, and outcomes of coronavirus disease 2019 in patients with immune-mediated inflammatory diseases and report data on the comparison of coronavirus disease 2019 between patients with inflammatory bowel disease and spondyloarthropathies. METHODS: A total of 101 patients with inflammatory bowel disease and spondyloarthropathies who had confirmed diagnosis of coronavirus disease 2019 were retrospectively analyzed. Demographics, comorbidities, immunosuppressive treatments, and the impact of immunosuppression on negative outcomes were assessed. RESULTS: The median age of the patients was 47 (38-57) years. The most common rheumatologic diagnosis was ankylosing spondylitis (n = 24), psoriatic arthritis (n = 17), and reactive arthritis (n = 1). In the inflammatory bowel disease group, 47 patients had ulcerative colitis, 11 Crohn’s disease, and 1 unclassified. The most commonly used treatments were biologics (55%) in the spondyloarthropathies group and aminosalicylates (66.1%) in the inflammatory bowel disease group. Overall, 18.8% of the patients required hospitalization, 5% developed severe complications, and 2% died. There were no significant differences in coronavirus disease 2019-related negative outcomes between spondyloarthropathies and inflammatory bowel disease patients. The median age was higher in the patients who required hospitalization [57 (46-66) vs 47 (38-57) years, P = .008]. Bilateral opacities on chest radiographs were more common in the patients who required hospitalization in the spondyloarthropathies group [88.9% vs 14.3%, P = .016]. Comorbidity was significantly associated with hospitalization in the inflammatory bowel disease group (P ≤ .05). Baseline therapy with biologics or immunosuppressives was not associated with severe coronavirus disease 2019 outcomes. CONCLUSION: Older age, comorbidities, and bilateral ground-glass opacities were associated with adverse outcomes, whereas specific immune-mediated inflammatory disease diagnoses or immunosuppressive treatments were not. |
format | Online Article Text |
id | pubmed-9524500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Turkish Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-95245002022-10-13 Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies Tozlu, Mukaddes Dilek, Gamze Kalçık Unan, Mehtap Kamanlı, Ayhan Tekeoğlu, İbrahim Uslan, Mustafa İhsan Nas, Kemal Turk J Gastroenterol Original Article BACKGROUND: We aimed to determine the clinical features, predictive factors associated with severe disease, and outcomes of coronavirus disease 2019 in patients with immune-mediated inflammatory diseases and report data on the comparison of coronavirus disease 2019 between patients with inflammatory bowel disease and spondyloarthropathies. METHODS: A total of 101 patients with inflammatory bowel disease and spondyloarthropathies who had confirmed diagnosis of coronavirus disease 2019 were retrospectively analyzed. Demographics, comorbidities, immunosuppressive treatments, and the impact of immunosuppression on negative outcomes were assessed. RESULTS: The median age of the patients was 47 (38-57) years. The most common rheumatologic diagnosis was ankylosing spondylitis (n = 24), psoriatic arthritis (n = 17), and reactive arthritis (n = 1). In the inflammatory bowel disease group, 47 patients had ulcerative colitis, 11 Crohn’s disease, and 1 unclassified. The most commonly used treatments were biologics (55%) in the spondyloarthropathies group and aminosalicylates (66.1%) in the inflammatory bowel disease group. Overall, 18.8% of the patients required hospitalization, 5% developed severe complications, and 2% died. There were no significant differences in coronavirus disease 2019-related negative outcomes between spondyloarthropathies and inflammatory bowel disease patients. The median age was higher in the patients who required hospitalization [57 (46-66) vs 47 (38-57) years, P = .008]. Bilateral opacities on chest radiographs were more common in the patients who required hospitalization in the spondyloarthropathies group [88.9% vs 14.3%, P = .016]. Comorbidity was significantly associated with hospitalization in the inflammatory bowel disease group (P ≤ .05). Baseline therapy with biologics or immunosuppressives was not associated with severe coronavirus disease 2019 outcomes. CONCLUSION: Older age, comorbidities, and bilateral ground-glass opacities were associated with adverse outcomes, whereas specific immune-mediated inflammatory disease diagnoses or immunosuppressive treatments were not. Turkish Society of Gastroenterology 2022-09-01 /pmc/articles/PMC9524500/ /pubmed/36134550 http://dx.doi.org/10.5152/tjg.2022.22181 Text en © Copyright 2022 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Original Article Tozlu, Mukaddes Dilek, Gamze Kalçık Unan, Mehtap Kamanlı, Ayhan Tekeoğlu, İbrahim Uslan, Mustafa İhsan Nas, Kemal Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies |
title | Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies |
title_full | Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies |
title_fullStr | Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies |
title_full_unstemmed | Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies |
title_short | Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies |
title_sort | clinical features and outcomes of coronavirus disease 2019 in patients with inflammatory bowel disease and spondyloarthropathies |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524500/ https://www.ncbi.nlm.nih.gov/pubmed/36134550 http://dx.doi.org/10.5152/tjg.2022.22181 |
work_keys_str_mv | AT tozlumukaddes clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies AT dilekgamze clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies AT kalcıkunanmehtap clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies AT kamanlıayhan clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies AT tekeogluibrahim clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies AT uslanmustafaihsan clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies AT naskemal clinicalfeaturesandoutcomesofcoronavirusdisease2019inpatientswithinflammatoryboweldiseaseandspondyloarthropathies |