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Factors associated with in-hospital mortality of patients admitted to an intensive care unit in a tertiary hospital in Malawi
OBJECTIVE: To determine factors associated with in-hospital death among patients admitted to ICU and to evaluate the predictive values of single severely deranged vital signs and several severity scoring systems. METHODS: A combined retrospective and prospective cohort study of patients admitted to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524689/ https://www.ncbi.nlm.nih.gov/pubmed/36178880 http://dx.doi.org/10.1371/journal.pone.0273647 |
Sumario: | OBJECTIVE: To determine factors associated with in-hospital death among patients admitted to ICU and to evaluate the predictive values of single severely deranged vital signs and several severity scoring systems. METHODS: A combined retrospective and prospective cohort study of patients admitted to the adult ICU in a tertiary hospital in Malawi was conducted between January 2017 and July 2019. Predefined potential risk factors for in-hospital death were studied with univariable and multivariable logistic regression models, and the performance of severity scores was assessed. RESULTS: The median age of the 822 participants was 31 years (IQR 21–43), and 50% were female. Several factors at admission were associated with in-hospital mortality: the presence of one or more severely deranged vital signs, adjusted odds ratio (aOR) 1.9 (1.4–2.6); treatment with vasopressor aOR 2.3 (1.6–3.4); received cardiopulmonary resuscitation aOR 1.7 (1.2–2.6) and treatment with mechanical ventilation aOR 1.5 (1.1–2.1). Having had surgery had a negative association with in-hospital mortality aOR 0.5 (0.4–0.7). The predictive accuracy of the severity scoring systems had varying sensitivities and specificities, but none were sufficiently accurate to be clinically useful. CONCLUSIONS: In conclusion, the presence of one or more severely deranged vital sign in patients admitted to ICU may be useful as a simple marker of an increased risk of in-hospital death. |
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