Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2

Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified N...

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Autores principales: Navetta-Modrov, Brianne, Ghebrehiwet, Berhane, Yao, Qingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524777/
https://www.ncbi.nlm.nih.gov/pubmed/36467900
http://dx.doi.org/10.2478/rir-2021-0005
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author Navetta-Modrov, Brianne
Ghebrehiwet, Berhane
Yao, Qingping
author_facet Navetta-Modrov, Brianne
Ghebrehiwet, Berhane
Yao, Qingping
author_sort Navetta-Modrov, Brianne
collection PubMed
description Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.
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spelling pubmed-95247772022-12-01 Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2 Navetta-Modrov, Brianne Ghebrehiwet, Berhane Yao, Qingping Rheumatol Immunol Res Case Report Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease. Sciendo 2021-04-13 /pmc/articles/PMC9524777/ /pubmed/36467900 http://dx.doi.org/10.2478/rir-2021-0005 Text en © 2021 Brianne Navetta-Modrov et al., published by Sciendo https://creativecommons.org/licenses/by-nc-nd/3.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Case Report
Navetta-Modrov, Brianne
Ghebrehiwet, Berhane
Yao, Qingping
Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2
title Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2
title_full Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2
title_fullStr Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2
title_full_unstemmed Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2
title_short Yao Syndrome: A Potential Role and Association of Vasoactive Intestinal Peptide with NOD2
title_sort yao syndrome: a potential role and association of vasoactive intestinal peptide with nod2
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524777/
https://www.ncbi.nlm.nih.gov/pubmed/36467900
http://dx.doi.org/10.2478/rir-2021-0005
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AT yaoqingping yaosyndromeapotentialroleandassociationofvasoactiveintestinalpeptidewithnod2

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