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Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus
Type I interferon (IFN-I) is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and the closely associated monogenic autoinflammatory disorders termed the “interferonopathies.” Recently, the cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524788/ https://www.ncbi.nlm.nih.gov/pubmed/36465073 http://dx.doi.org/10.2478/rir-2021-0023 |
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author | Hagiwara, Audrey M. Moore, Richard E. Wallace, Daniel J. Ishimori, Mariko Jefferies, Caroline A. |
author_facet | Hagiwara, Audrey M. Moore, Richard E. Wallace, Daniel J. Ishimori, Mariko Jefferies, Caroline A. |
author_sort | Hagiwara, Audrey M. |
collection | PubMed |
description | Type I interferon (IFN-I) is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and the closely associated monogenic autoinflammatory disorders termed the “interferonopathies.” Recently, the cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have been identified as having important, if not central, roles in driving IFN-I expression in response to self-DNA. This review highlights the many ways in which this pathway is regulated in order to prevent self-DNA recognition and underlines the importance of maintaining tight control in order to prevent autoimmune disease. We will discuss the murine and human studies that have implicated the cGAS-STING pathway as being an important contributor to breakdown in tolerance in SLE and highlight the potential therapeutic application of this knowledge for the treatment of SLE. |
format | Online Article Text |
id | pubmed-9524788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-95247882022-12-01 Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus Hagiwara, Audrey M. Moore, Richard E. Wallace, Daniel J. Ishimori, Mariko Jefferies, Caroline A. Rheumatol Immunol Res Review Type I interferon (IFN-I) is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and the closely associated monogenic autoinflammatory disorders termed the “interferonopathies.” Recently, the cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have been identified as having important, if not central, roles in driving IFN-I expression in response to self-DNA. This review highlights the many ways in which this pathway is regulated in order to prevent self-DNA recognition and underlines the importance of maintaining tight control in order to prevent autoimmune disease. We will discuss the murine and human studies that have implicated the cGAS-STING pathway as being an important contributor to breakdown in tolerance in SLE and highlight the potential therapeutic application of this knowledge for the treatment of SLE. Sciendo 2021-12-15 /pmc/articles/PMC9524788/ /pubmed/36465073 http://dx.doi.org/10.2478/rir-2021-0023 Text en © 2021 Audrey M. Hagiwara et al., published by Sciendo https://creativecommons.org/licenses/by-nc-nd/3.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Review Hagiwara, Audrey M. Moore, Richard E. Wallace, Daniel J. Ishimori, Mariko Jefferies, Caroline A. Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus |
title | Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus |
title_full | Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus |
title_fullStr | Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus |
title_full_unstemmed | Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus |
title_short | Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus |
title_sort | regulation of cgas-sting pathway - implications for systemic lupus erythematosus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524788/ https://www.ncbi.nlm.nih.gov/pubmed/36465073 http://dx.doi.org/10.2478/rir-2021-0023 |
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