CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Identification of new markers associated with long-term efficacy in patients treated with CAR T cells is a current medical need, particularly in diseases such as multiple myeloma. In this study, we address the impact of CAR density on the functionality of BCMA CAR T cells. Functional and transcripti...

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Detalles Bibliográficos
Autores principales: Rodriguez-Marquez, Paula, Calleja-Cervantes, Maria E., Serrano, Guillermo, Oliver-Caldes, Aina, Palacios-Berraquero, Maria L., Martin-Mallo, Angel, Calviño, Cristina, Español-Rego, Marta, Ceballos, Candela, Lozano, Teresa, San Martin-Uriz, Patxi, Vilas-Zornoza, Amaia, Rodriguez-Diaz, Saray, Martinez-Turrillas, Rebeca, Jauregui, Patricia, Alignani, Diego, Viguria, Maria C., Redondo, Margarita, Pascal, Mariona, Martin-Antonio, Beatriz, Juan, Manel, Urbano-Ispizua, Alvaro, Rodriguez-Otero, Paula, Alfonso-Pierola, Ana, Paiva, Bruno, Lasarte, Juan J., Inoges, Susana, Lopez-Diaz de Cerio, Ascension, San-Miguel, Jesus, Fernandez de Larrea, Carlos, Hernaez, Mikel, Rodriguez-Madoz, Juan R., Prosper, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524842/
https://www.ncbi.nlm.nih.gov/pubmed/36179026
http://dx.doi.org/10.1126/sciadv.abo0514

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