Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview

Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlyin...

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Autores principales: Miao, Xiangwan, Wang, Beilei, Chen, Kaili, Ding, Rui, Wu, Jichang, Pan, Yi, Ji, Peilin, Ye, Bin, Xiang, Mingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524856/
https://www.ncbi.nlm.nih.gov/pubmed/36185215
http://dx.doi.org/10.3389/fonc.2022.1008361
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author Miao, Xiangwan
Wang, Beilei
Chen, Kaili
Ding, Rui
Wu, Jichang
Pan, Yi
Ji, Peilin
Ye, Bin
Xiang, Mingliang
author_facet Miao, Xiangwan
Wang, Beilei
Chen, Kaili
Ding, Rui
Wu, Jichang
Pan, Yi
Ji, Peilin
Ye, Bin
Xiang, Mingliang
author_sort Miao, Xiangwan
collection PubMed
description Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the “vital” cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.
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spelling pubmed-95248562022-10-01 Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview Miao, Xiangwan Wang, Beilei Chen, Kaili Ding, Rui Wu, Jichang Pan, Yi Ji, Peilin Ye, Bin Xiang, Mingliang Front Oncol Oncology Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the “vital” cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9524856/ /pubmed/36185215 http://dx.doi.org/10.3389/fonc.2022.1008361 Text en Copyright © 2022 Miao, Wang, Chen, Ding, Wu, Pan, Ji, Ye and Xiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Miao, Xiangwan
Wang, Beilei
Chen, Kaili
Ding, Rui
Wu, Jichang
Pan, Yi
Ji, Peilin
Ye, Bin
Xiang, Mingliang
Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
title Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
title_full Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
title_fullStr Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
title_full_unstemmed Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
title_short Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
title_sort perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: an overview
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524856/
https://www.ncbi.nlm.nih.gov/pubmed/36185215
http://dx.doi.org/10.3389/fonc.2022.1008361
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