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The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer

The aim of this study is to clarify the association between lymphovascular invasion (LVI) and/or perineural invasion (PNI) and the clinical characteristics and prognostic importance of rectal cancer, to provide a basis for early adjuvant treatment of rectal cancer. We retrospectively analyzed patien...

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Autores principales: Chen, Tong, Wang, Mingchuan, Cheng, Xianbin, Wang, Yizhuo, Jiang, Yang, Fang, Xuedong, Xiao, Huijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524871/
https://www.ncbi.nlm.nih.gov/pubmed/36181060
http://dx.doi.org/10.1097/MD.0000000000030687
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author Chen, Tong
Wang, Mingchuan
Cheng, Xianbin
Wang, Yizhuo
Jiang, Yang
Fang, Xuedong
Xiao, Huijie
author_facet Chen, Tong
Wang, Mingchuan
Cheng, Xianbin
Wang, Yizhuo
Jiang, Yang
Fang, Xuedong
Xiao, Huijie
author_sort Chen, Tong
collection PubMed
description The aim of this study is to clarify the association between lymphovascular invasion (LVI) and/or perineural invasion (PNI) and the clinical characteristics and prognostic importance of rectal cancer, to provide a basis for early adjuvant treatment of rectal cancer. We retrospectively analyzed patients diagnosed with rectal cancer. This study involved rectal cancer tissue samples were obtained by surgical methods. Data on histological form, tumor classification, tumor size, gross growth pattern, blood and lymphatic vessel invasion, and PNI of the slice by HE staining were obtained from pathological examination. Immunohistochemical analysis of tissue samples was performed to determine p53 and EGFR expressions. There were 330 rectal cancer patients included in the study. LVI and/or PNI can be used as a high-risk factor for the prognosis of rectal cancer, predict prognostic survival, and guide adjuvant therapy. The detection rates of LVI and PNI were 32.1% and 16.1%. Differentiation grade, Union for International Cancer Control staging, tumor-lymph node-metastasis staging are significantly related to LVI or PNI. Multivariate logistic regression analysis shows that poor differentiation and N ≥ 1 can be used as independent risk factors and predictive factors for LVI. At the same time, poor differentiation and T > 3 is an independent risk factor for PNI. Only poor differentiation is the risk factor for poor prognosis in Cox risk regression analysis. In addition, the simultaneous occurrence of LVI and PNI is an independent prognostic factor.
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spelling pubmed-95248712022-10-03 The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer Chen, Tong Wang, Mingchuan Cheng, Xianbin Wang, Yizhuo Jiang, Yang Fang, Xuedong Xiao, Huijie Medicine (Baltimore) Research Article The aim of this study is to clarify the association between lymphovascular invasion (LVI) and/or perineural invasion (PNI) and the clinical characteristics and prognostic importance of rectal cancer, to provide a basis for early adjuvant treatment of rectal cancer. We retrospectively analyzed patients diagnosed with rectal cancer. This study involved rectal cancer tissue samples were obtained by surgical methods. Data on histological form, tumor classification, tumor size, gross growth pattern, blood and lymphatic vessel invasion, and PNI of the slice by HE staining were obtained from pathological examination. Immunohistochemical analysis of tissue samples was performed to determine p53 and EGFR expressions. There were 330 rectal cancer patients included in the study. LVI and/or PNI can be used as a high-risk factor for the prognosis of rectal cancer, predict prognostic survival, and guide adjuvant therapy. The detection rates of LVI and PNI were 32.1% and 16.1%. Differentiation grade, Union for International Cancer Control staging, tumor-lymph node-metastasis staging are significantly related to LVI or PNI. Multivariate logistic regression analysis shows that poor differentiation and N ≥ 1 can be used as independent risk factors and predictive factors for LVI. At the same time, poor differentiation and T > 3 is an independent risk factor for PNI. Only poor differentiation is the risk factor for poor prognosis in Cox risk regression analysis. In addition, the simultaneous occurrence of LVI and PNI is an independent prognostic factor. Lippincott Williams & Wilkins 2022-09-30 /pmc/articles/PMC9524871/ /pubmed/36181060 http://dx.doi.org/10.1097/MD.0000000000030687 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Tong
Wang, Mingchuan
Cheng, Xianbin
Wang, Yizhuo
Jiang, Yang
Fang, Xuedong
Xiao, Huijie
The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer
title The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer
title_full The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer
title_fullStr The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer
title_full_unstemmed The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer
title_short The complementary role of lymphovascular invasion and perineural invasion in the TNM staging process of rectal cancer
title_sort complementary role of lymphovascular invasion and perineural invasion in the tnm staging process of rectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524871/
https://www.ncbi.nlm.nih.gov/pubmed/36181060
http://dx.doi.org/10.1097/MD.0000000000030687
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