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Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study

The main purpose of this study was to build a prediction model for male breast cancer (MBC) patients to predict the possibility of distant metastasis. The Surveillance, Epidemiology, and End Results database was used to obtain data on patients with MBC. The patients were divided into a training set...

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Autores principales: Wang, Dasong, Yang, Lei, Yang, Yan, Chen, Maoshan, Yang, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524899/
https://www.ncbi.nlm.nih.gov/pubmed/36181026
http://dx.doi.org/10.1097/MD.0000000000030978
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author Wang, Dasong
Yang, Lei
Yang, Yan
Chen, Maoshan
Yang, Hongwei
author_facet Wang, Dasong
Yang, Lei
Yang, Yan
Chen, Maoshan
Yang, Hongwei
author_sort Wang, Dasong
collection PubMed
description The main purpose of this study was to build a prediction model for male breast cancer (MBC) patients to predict the possibility of distant metastasis. The Surveillance, Epidemiology, and End Results database was used to obtain data on patients with MBC. The patients were divided into a training set and a validation set at a ratio of 7:3. The risk variables of distant metastasis in the training set were determined by univariate and multivariate logistic regression analyses. And then we integrated those risk factors to construct the nomogram. The prediction nomogram was further verified in the verification set. The discrimination and calibration of the nomogram were evaluated by the area under the receiver operating characteristic curve, calibration plots, respectively. A total of 1974 patients (1381 in training set and 593 in validation set) were eligible for final inclusion, of whom 149 (7.55%) had distant metastasis at the diagnosed time. Multivariate logistic regression analyses presented that age, T stage, N stage, and hormone receptor status were independent risk factors for distant metastasis at initial diagnosis of male breast cancer. Finally, the 4 variables were combined to construct the nomogram. The area under the curve values for the nomogram established in the training set and validation set were 0.8224 (95%CI: 0.7796–0.8652) and 0.8631 (95%CI: 0.7937–0.9326), suggesting that the nomogram had good predictive power. The calibration plots illustrated an acceptable correlation between the prediction by nomogram and the actual observation, as the calibration curve was closed to the diagonal bisector line. An easy-to-use nomogram, being proven to be with reliable discrimination ability and accuracy, was established to predict distant metastasis for male patients with breast cancer using the easily available risk factors.
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spelling pubmed-95248992022-10-03 Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study Wang, Dasong Yang, Lei Yang, Yan Chen, Maoshan Yang, Hongwei Medicine (Baltimore) Research Article The main purpose of this study was to build a prediction model for male breast cancer (MBC) patients to predict the possibility of distant metastasis. The Surveillance, Epidemiology, and End Results database was used to obtain data on patients with MBC. The patients were divided into a training set and a validation set at a ratio of 7:3. The risk variables of distant metastasis in the training set were determined by univariate and multivariate logistic regression analyses. And then we integrated those risk factors to construct the nomogram. The prediction nomogram was further verified in the verification set. The discrimination and calibration of the nomogram were evaluated by the area under the receiver operating characteristic curve, calibration plots, respectively. A total of 1974 patients (1381 in training set and 593 in validation set) were eligible for final inclusion, of whom 149 (7.55%) had distant metastasis at the diagnosed time. Multivariate logistic regression analyses presented that age, T stage, N stage, and hormone receptor status were independent risk factors for distant metastasis at initial diagnosis of male breast cancer. Finally, the 4 variables were combined to construct the nomogram. The area under the curve values for the nomogram established in the training set and validation set were 0.8224 (95%CI: 0.7796–0.8652) and 0.8631 (95%CI: 0.7937–0.9326), suggesting that the nomogram had good predictive power. The calibration plots illustrated an acceptable correlation between the prediction by nomogram and the actual observation, as the calibration curve was closed to the diagonal bisector line. An easy-to-use nomogram, being proven to be with reliable discrimination ability and accuracy, was established to predict distant metastasis for male patients with breast cancer using the easily available risk factors. Lippincott Williams & Wilkins 2022-09-30 /pmc/articles/PMC9524899/ /pubmed/36181026 http://dx.doi.org/10.1097/MD.0000000000030978 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Wang, Dasong
Yang, Lei
Yang, Yan
Chen, Maoshan
Yang, Hongwei
Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study
title Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study
title_full Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study
title_fullStr Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study
title_full_unstemmed Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study
title_short Nomogram for predicting distant metastasis of male breast cancer: A SEER population-based study
title_sort nomogram for predicting distant metastasis of male breast cancer: a seer population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524899/
https://www.ncbi.nlm.nih.gov/pubmed/36181026
http://dx.doi.org/10.1097/MD.0000000000030978
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