Cargando…

Characterizing inflammatory markers in highly aggressive soft tissue sarcomas

The prognosis for soft tissue sarcomas (STSs) is poor, especially for highly aggressive STSs, and the details of prognostic factors are unknown. This study aimed to investigate the prognostic factors for STSs in hematologic inflammatory markers. We included 22 patients with STSs treated at our insti...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashimoto, Kazuhiko, Nishimura, Shunji, Shinyashiki, Yu, Ito, Tomohiko, Akagi, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524936/
https://www.ncbi.nlm.nih.gov/pubmed/36181081
http://dx.doi.org/10.1097/MD.0000000000030688
_version_ 1784800599037968384
author Hashimoto, Kazuhiko
Nishimura, Shunji
Shinyashiki, Yu
Ito, Tomohiko
Akagi, Masao
author_facet Hashimoto, Kazuhiko
Nishimura, Shunji
Shinyashiki, Yu
Ito, Tomohiko
Akagi, Masao
author_sort Hashimoto, Kazuhiko
collection PubMed
description The prognosis for soft tissue sarcomas (STSs) is poor, especially for highly aggressive STSs, and the details of prognostic factors are unknown. This study aimed to investigate the prognostic factors for STSs in hematologic inflammatory markers. We included 22 patients with STSs treated at our institution. The STSs were histologically classified as follows: undifferentiated pleomorphic sarcoma, 7 cases; myxofibrosarcoma, 6 cases; and malignant peripheral nerve sheath tumor, 2 cases. The average patient age was 72.06 years. The numbers of patients who underwent each procedure were as follows: wide resection, 7; wide resection and flap, 2; marginal resection, 2; wide resection and radiation, 1; additional wide resection with flap, 1; wide resection and skin graft, 1; and radiotherapy only, 1. The median follow-up period was 26 months (3–92 months). The outcomes were as follows: continuous disease free, 6 cases; no evidence of disease, 6 cases; alive with disease, 1 case; and died of disease, 2 cases. Pretreatment blood examinations for C-reactive protein (CRP) and albumin levels; neutrophil, lymphocyte, and white blood cell (WBC) counts; and neutrophil/lymphocyte (N/L) ratio were investigated and correlated with tumor size, tissue grade, and maximum standardized uptake value (SUVmax). CRP level and neutrophil and WBC counts were positively correlated with tissue grade and SUVmax. N/L ratio was positively correlated with tumor size and SUVmax. CRP level, WBC and neutrophil counts, and N/L ratio may be poor prognostic factors for highly aggressive STSs.
format Online
Article
Text
id pubmed-9524936
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-95249362022-10-03 Characterizing inflammatory markers in highly aggressive soft tissue sarcomas Hashimoto, Kazuhiko Nishimura, Shunji Shinyashiki, Yu Ito, Tomohiko Akagi, Masao Medicine (Baltimore) Research Article The prognosis for soft tissue sarcomas (STSs) is poor, especially for highly aggressive STSs, and the details of prognostic factors are unknown. This study aimed to investigate the prognostic factors for STSs in hematologic inflammatory markers. We included 22 patients with STSs treated at our institution. The STSs were histologically classified as follows: undifferentiated pleomorphic sarcoma, 7 cases; myxofibrosarcoma, 6 cases; and malignant peripheral nerve sheath tumor, 2 cases. The average patient age was 72.06 years. The numbers of patients who underwent each procedure were as follows: wide resection, 7; wide resection and flap, 2; marginal resection, 2; wide resection and radiation, 1; additional wide resection with flap, 1; wide resection and skin graft, 1; and radiotherapy only, 1. The median follow-up period was 26 months (3–92 months). The outcomes were as follows: continuous disease free, 6 cases; no evidence of disease, 6 cases; alive with disease, 1 case; and died of disease, 2 cases. Pretreatment blood examinations for C-reactive protein (CRP) and albumin levels; neutrophil, lymphocyte, and white blood cell (WBC) counts; and neutrophil/lymphocyte (N/L) ratio were investigated and correlated with tumor size, tissue grade, and maximum standardized uptake value (SUVmax). CRP level and neutrophil and WBC counts were positively correlated with tissue grade and SUVmax. N/L ratio was positively correlated with tumor size and SUVmax. CRP level, WBC and neutrophil counts, and N/L ratio may be poor prognostic factors for highly aggressive STSs. Lippincott Williams & Wilkins 2022-09-30 /pmc/articles/PMC9524936/ /pubmed/36181081 http://dx.doi.org/10.1097/MD.0000000000030688 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hashimoto, Kazuhiko
Nishimura, Shunji
Shinyashiki, Yu
Ito, Tomohiko
Akagi, Masao
Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
title Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
title_full Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
title_fullStr Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
title_full_unstemmed Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
title_short Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
title_sort characterizing inflammatory markers in highly aggressive soft tissue sarcomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524936/
https://www.ncbi.nlm.nih.gov/pubmed/36181081
http://dx.doi.org/10.1097/MD.0000000000030688
work_keys_str_mv AT hashimotokazuhiko characterizinginflammatorymarkersinhighlyaggressivesofttissuesarcomas
AT nishimurashunji characterizinginflammatorymarkersinhighlyaggressivesofttissuesarcomas
AT shinyashikiyu characterizinginflammatorymarkersinhighlyaggressivesofttissuesarcomas
AT itotomohiko characterizinginflammatorymarkersinhighlyaggressivesofttissuesarcomas
AT akagimasao characterizinginflammatorymarkersinhighlyaggressivesofttissuesarcomas