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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

BACKGROUND: Apramycin is under development for human use as EBL-1003, a crystalline free base of apramycin, in face of increasing incidence of multidrug-resistant bacteria. Both toxicity and cross-resistance, commonly seen for other aminoglycosides, appear relatively low owing to its distinct chemic...

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Detalles Bibliográficos
Autores principales:	Zhao, Chenyan, Chirkova, Anna, Rosenborg, Staffan, Palma Villar, Rodrigo, Lindberg, Johan, Hobbie, Sven N, Friberg, Lena E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525081/ https://www.ncbi.nlm.nih.gov/pubmed/35849148 http://dx.doi.org/10.1093/jac/dkac225

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