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Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats

Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the un...

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Autores principales: Huang, Luqiang, Wu, Wenxin, Huang, Linshan, Zhong, Jiaze, Chen, Lei, Wang, Meiying, Chen, Huibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525105/
https://www.ncbi.nlm.nih.gov/pubmed/36185650
http://dx.doi.org/10.3389/fnut.2022.1003627
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author Huang, Luqiang
Wu, Wenxin
Huang, Linshan
Zhong, Jiaze
Chen, Lei
Wang, Meiying
Chen, Huibin
author_facet Huang, Luqiang
Wu, Wenxin
Huang, Linshan
Zhong, Jiaze
Chen, Lei
Wang, Meiying
Chen, Huibin
author_sort Huang, Luqiang
collection PubMed
description Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury.
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spelling pubmed-95251052022-10-01 Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats Huang, Luqiang Wu, Wenxin Huang, Linshan Zhong, Jiaze Chen, Lei Wang, Meiying Chen, Huibin Front Nutr Nutrition Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9525105/ /pubmed/36185650 http://dx.doi.org/10.3389/fnut.2022.1003627 Text en Copyright © 2022 Huang, Wu, Huang, Zhong, Chen, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Huang, Luqiang
Wu, Wenxin
Huang, Linshan
Zhong, Jiaze
Chen, Lei
Wang, Meiying
Chen, Huibin
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
title Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
title_full Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
title_fullStr Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
title_full_unstemmed Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
title_short Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
title_sort antarctic krill (euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525105/
https://www.ncbi.nlm.nih.gov/pubmed/36185650
http://dx.doi.org/10.3389/fnut.2022.1003627
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