Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Infantile (fetal and neonatal) megakaryocytes (Mks) have a distinct phenotype consisting of hyperproliferation, limited morphogenesis, and low platelet production capacity. These properties contribute to clinical problems that include thrombocytopenia in neonates, delayed platelet engraftment in rec...

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Detalles Bibliográficos
Autores principales: Elagib, Kamaleldin E., Brock, Ashton, Clementelli, Cara M., Mosoyan, Goar, Delehanty, Lorrie L., Sahu, Ranjit K., Pacheco-Benichou, Alexandra, Fruit, Corinne, Besson, Thierry, Morris, Stephan W., Eto, Koji, Jobaliya, Chintan, French, Deborah L., Gadue, Paul, Singh, Sandeep, Shi, Xinrui, Qin, Fujun, Cornelison, Robert, Li, Hui, Iancu-Rubin, Camelia, Goldfarb, Adam N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525118/
https://www.ncbi.nlm.nih.gov/pubmed/35925681
http://dx.doi.org/10.1172/JCI154839

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