TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons

The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide–expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also modulating nonfeeding behaviors. Besides AGRP, thes...

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Detalles Bibliográficos
Autores principales: Xie, Di, Stutz, Bernardo, Li, Feng, Chen, Fan, Lv, Haining, Sestan-Pesa, Matija, Catarino, Jonatas, Gu, Jianlei, Zhao, Hongyu, Stoddard, Christopher E., Carmichael, Gordon G., Shanabrough, Marya, Taylor, Hugh S., Liu, Zhong-Wu, Gao, Xiao-Bing, Horvath, Tamas L., Huang, Yingqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525119/
https://www.ncbi.nlm.nih.gov/pubmed/36189793
http://dx.doi.org/10.1172/JCI162365

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