Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

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Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel co-option have mainly focused on “hijacker” tumor cells, whereas the function of the “hijackee” sinusoidal blood vessels has not...

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Detalles Bibliográficos
Autores principales: Qi, Ming, Fan, Shuran, Huang, Maohua, Pan, Jinghua, Li, Yong, Miao, Qun, Lyu, Wenyu, Li, Xiaobo, Deng, Lijuan, Qiu, Shenghui, Liu, Tongzheng, Deng, Weiqing, Chu, Xiaodong, Jiang, Chang, He, Wenzhuo, Xia, Liangping, Yang, Yunlong, Hong, Jian, Qi, Qi, Yin, Wenqian, Liu, Xiangning, Shi, Changzheng, Chen, Minfeng, Ye, Wencai, Zhang, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525122/
https://www.ncbi.nlm.nih.gov/pubmed/35951441
http://dx.doi.org/10.1172/JCI157399
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