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The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review

Spinosin, a natural flavone-C-glycoside that is mainly isolated from the seeds of Ziziphus jujuba Mill. var. spinosa. It exerts the effects to ameliorate the neurological disorders, such as hypnosis effects, improvement of cognitive function, sedation effects, and anxiolytic effects, as well as anti...

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Autores principales: Kuang, Xiaolan, She, Ganshu, Ma, Ting, Cai, Wanna, Zhao, Jingjing, Liu, Bo, Xu, Fangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525219/
https://www.ncbi.nlm.nih.gov/pubmed/36193419
http://dx.doi.org/10.3389/fphar.2022.938395
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author Kuang, Xiaolan
She, Ganshu
Ma, Ting
Cai, Wanna
Zhao, Jingjing
Liu, Bo
Xu, Fangfang
author_facet Kuang, Xiaolan
She, Ganshu
Ma, Ting
Cai, Wanna
Zhao, Jingjing
Liu, Bo
Xu, Fangfang
author_sort Kuang, Xiaolan
collection PubMed
description Spinosin, a natural flavone-C-glycoside that is mainly isolated from the seeds of Ziziphus jujuba Mill. var. spinosa. It exerts the effects to ameliorate the neurological disorders, such as hypnosis effects, improvement of cognitive function, sedation effects, and anxiolytic effects, as well as anti-melanogenic effect, cardioprotective effects, and anti-cancer activity. However, the insufficient basic research, unclear mechanisms, and poor bioavailability may limit the prospects of spinosin in clinical utilization. In this review, we comprehensively summarized the latest information on the pharmacology, pharmacokinetics, toxicity, and NMR characteristic of spinosin, to evaluate its potential therapeutic for clinical application, hoping to provide some rational perspective for the innovative agent development and usage of spinosin in future.
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spelling pubmed-95252192022-10-02 The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review Kuang, Xiaolan She, Ganshu Ma, Ting Cai, Wanna Zhao, Jingjing Liu, Bo Xu, Fangfang Front Pharmacol Pharmacology Spinosin, a natural flavone-C-glycoside that is mainly isolated from the seeds of Ziziphus jujuba Mill. var. spinosa. It exerts the effects to ameliorate the neurological disorders, such as hypnosis effects, improvement of cognitive function, sedation effects, and anxiolytic effects, as well as anti-melanogenic effect, cardioprotective effects, and anti-cancer activity. However, the insufficient basic research, unclear mechanisms, and poor bioavailability may limit the prospects of spinosin in clinical utilization. In this review, we comprehensively summarized the latest information on the pharmacology, pharmacokinetics, toxicity, and NMR characteristic of spinosin, to evaluate its potential therapeutic for clinical application, hoping to provide some rational perspective for the innovative agent development and usage of spinosin in future. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9525219/ /pubmed/36193419 http://dx.doi.org/10.3389/fphar.2022.938395 Text en Copyright © 2022 Kuang, She, Ma, Cai, Zhao, Liu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kuang, Xiaolan
She, Ganshu
Ma, Ting
Cai, Wanna
Zhao, Jingjing
Liu, Bo
Xu, Fangfang
The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
title The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
title_full The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
title_fullStr The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
title_full_unstemmed The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
title_short The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
title_sort pharmacology, pharmacokinetics, and toxicity of spinosin: a mini review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525219/
https://www.ncbi.nlm.nih.gov/pubmed/36193419
http://dx.doi.org/10.3389/fphar.2022.938395
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