Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells

Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function in esophageal squamous carcinoma (ESCC) are poorly understood. We found that the ZNF154 promoter is hypermethylated in ESCC and portends poor prog...

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Detalles Bibliográficos
Autores principales: He, Wenting, Lin, Shiyong, Guo, Yi, Wu, Yuanzhong, Zhang, Lu-Lu, Deng, Qiling, Du, Zi-Ming, Wei, Mingbiao, Zhu, Weijie, Chen, Wan-Juan, Shao, Jian-Yong, Xu, Guo-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525237/
https://www.ncbi.nlm.nih.gov/pubmed/36064578
http://dx.doi.org/10.1038/s41388-022-02366-y

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