Extreme conditions affect neuronal oscillations of cerebral cortices in humans in the China Space Station and on Earth

Rhythmical oscillations of neural populations can reflect working memory performance. However, whether neuronal oscillations of the cerebral cortex change in extreme environments, especially in a space station, remains unclear. Here, we recorded electroencephalography (EEG) signals when volunteers and astronauts were executing a memory task in extreme working conditions. Our experiments showed that two extreme conditions affect neuronal oscillations of the cerebral cortex and manifest in different ways. Lengthy periods of mental work impairs the gating mechanism formed by theta-gamma phase-amplitude coupling of two cortical areas, and sleep deprivation disrupts synaptic homeostasis, as reflected by the substantial increase in theta wave activity in the cortical frontal-central area. In addition, we excluded the possibility that nutritional supply or psychological situations caused decoupled theta-gamma phase-amplitude coupling or an imbalance in theta wave activity increase. Therefore, we speculate that the decoupled theta-gamma phase-amplitude coupling detected in astronauts results from their lengthy periods of mental work in the China Space Station. Furthermore, comparing preflight and inflight experiments, we find that long-term spaceflight and other hazards in the space station could worsen this decoupling evolution. This particular neuronal oscillation mechanism in the cerebral cortex could guide countermeasures for the inadaptability of humans working in spaceflight.