Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

OBJECTIVE: Tregs are crucial for immune regulation, and environment‐driven adaptation of effector (e)Tregs is essential for local functioning. However, the extent of human Treg heterogeneity in inflammatory settings is unclear. METHODS: We combined single‐cell RNA‐ and TCR‐sequencing on Tregs derive...

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Detalles Bibliográficos
Autores principales: Lutter, Lisanne, van der Wal, M Marlot, Brand, Eelco C, Maschmeyer, Patrick, Vastert, Sebastiaan, Mashreghi, Mir‐Farzin, van Loosdregt, Jorg, van Wijk, Femke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525321/
https://www.ncbi.nlm.nih.gov/pubmed/36204213
http://dx.doi.org/10.1002/cti2.1420

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