Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides

Excess brain cholesterol is strongly implicated in the pathogenesis of Alzheimer’s disease (AD). Here we evaluated how the presence of a cholesterol-binding site (CBS) in the transmembrane and juxtamembrane regions of the amyloid precursor protein (APP) regulates its processing. We generated nine po...

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Detalles Bibliográficos
Autores principales: Hanbouch, Linda, Schaack, Béatrice, Kasri, Amal, Fontaine, Gaëlle, Gkanatsiou, Eleni, Brinkmalm, Gunnar, Camporesi, Elena, Portelius, Erik, Blennow, Kaj, Mourier, Gilles, Gilles, Nicolas, Millan, Mark J., Marquer, Catherine, Zetterberg, Henrik, Boussicault, Lydie, Potier, Marie-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525381/
https://www.ncbi.nlm.nih.gov/pubmed/36076005
http://dx.doi.org/10.1007/s12035-022-03025-9

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