Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins

Colchicine is an anti-inflammatory drug with a narrow therapeutic index. Its binding to tubulin prevents microtubule polymerization; however, little is known about how depolymerization of microtubules interferes with the phagocytosis function of Kupffer cells (KC). Here, we applied functional intrav...

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Detalles Bibliográficos
Autores principales: Hassan, Reham, Myllys, Maiju, Brackhagen, Lisa, Hobloss, Zaynab, González, Daniela, Seddek, Abdel-latif, Friebel, Adrian, Hoehme, Stefan, Marchan, Rosemarie, Trauner, Michael, Hengstler, Jan G., Ghallab, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525399/
https://www.ncbi.nlm.nih.gov/pubmed/36102954
http://dx.doi.org/10.1007/s00204-022-03353-8

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