Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons

Impairments in mitochondrial physiology play a role in the progression of multiple neurodegenerative conditions, including peripheral neuropathy in diabetes. Blockade of muscarinic acetylcholine type 1 receptor (M(1)R) with specific/selective antagonists prevented mitochondrial dysfunction and rever...

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Detalles Bibliográficos
Autores principales: Naznin, Farhana, Waise, T. M. Zaved, Fernyhough, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525428/
https://www.ncbi.nlm.nih.gov/pubmed/36002781
http://dx.doi.org/10.1007/s12035-022-03003-1

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