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Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Medulloblastoma is the most common malignant brain tumour in children. Genomic studies have identified distinct disease subgroups: wnt/wingless (WNT), sonic hedgehog (SHH), and non-WNT/non-SHH, comprising group 3 and group 4. Alterations in WNT and SHH signalling form the pathogenetic basis for thei...

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Detalles Bibliográficos
Autores principales:	Chen, Zhuoyao, Ioris, Rafael M., Richardson, Stacey, Van Ess, Ava N., Vendrell, Iolanda, Kessler, Benedikt M., Buffa, Francesca M., Busino, Luca, Clifford, Steven C., Bullock, Alex N., D’Angiolella, Vincenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525703/ https://www.ncbi.nlm.nih.gov/pubmed/35379950 http://dx.doi.org/10.1038/s41418-022-00983-4

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