Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD(+) and SIRT3

Neurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in an ERK-dependent fashion, decreasing both respiration and intracellular NAD(+)...

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Detalles Bibliográficos
Autores principales: Masgras, Ionica, Cannino, Giuseppe, Ciscato, Francesco, Sanchez-Martin, Carlos, Darvishi, Fereshteh Babaei, Scantamburlo, Francesca, Pizzi, Marco, Menga, Alessio, Fregona, Dolores, Castegna, Alessandra, Rasola, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525706/
https://www.ncbi.nlm.nih.gov/pubmed/35393510
http://dx.doi.org/10.1038/s41418-022-00991-4

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