AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

The fungal pathogen Cryptococcus neoformans is a leading cause of meningoencephalitis in the immunocompromised. As current antifungal treatments are toxic to the host, costly, limited in their efficacy, and associated with drug resistance, there is an urgent need to identify vulnerabilities in funga...

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Detalles Bibliográficos
Autores principales: Wizrah, Maha S.I., Chua, Sheena M.H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M.L., Robertson, Avril A.B., Kappler, Ulrike, Kobe, Bostjan, Fraser, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525906/
https://www.ncbi.nlm.nih.gov/pubmed/36063996
http://dx.doi.org/10.1016/j.jbc.2022.102453

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