α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention

Γ-Crystallins play a major role in age-related lens transparency. Their destabilization by mutations and physical chemical insults are associated with cataract formation. Therefore, drugs that increase their stability should have anticataract properties. To this end, we screened 2560 Federal Drug Ag...

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Detalles Bibliográficos
Autores principales: Islam, Sidra, Do, Michael T., Frank, Brett S., Hom, Grant L., Wheeler, Samuel, Fujioka, Hisashi, Wang, Benlian, Minocha, Geeta, Sell, David R., Fan, Xingjun, Lampi, Kirsten J., Monnier, Vincent M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525908/
https://www.ncbi.nlm.nih.gov/pubmed/36037967
http://dx.doi.org/10.1016/j.jbc.2022.102417

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