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genomicSimulation: fast R functions for stochastic simulation of breeding programs

Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity req...

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Autores principales: Villiers, Kira, Dinglasan, Eric, Hayes, Ben J, Voss-Fels, Kai P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526041/
https://www.ncbi.nlm.nih.gov/pubmed/36053200
http://dx.doi.org/10.1093/g3journal/jkac216
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author Villiers, Kira
Dinglasan, Eric
Hayes, Ben J
Voss-Fels, Kai P
author_facet Villiers, Kira
Dinglasan, Eric
Hayes, Ben J
Voss-Fels, Kai P
author_sort Villiers, Kira
collection PubMed
description Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity required to maintain gains in the future. Here, we present genomicSimulation, a fast and flexible tool for the stochastic simulation of crossing and selection based on real genotypes. It is fully written in C for high execution speeds, has minimal dependencies, and is available as an R package for the integration with R’s broad range of analysis and visualization tools. Comparisons of a simulated recreation of a breeding program to a real data set demonstrate the simulated offspring from the tool correctly show key population features, such as genomic relationships and approximate linkage disequilibrium patterns. Both versions of genomicSimulation are freely available on GitHub: The R package version at https://github.com/vllrs/genomicSimulation/ and the C library version at https://github.com/vllrs/genomicSimulationC/.
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spelling pubmed-95260412022-10-03 genomicSimulation: fast R functions for stochastic simulation of breeding programs Villiers, Kira Dinglasan, Eric Hayes, Ben J Voss-Fels, Kai P G3 (Bethesda) Software and Data Resources Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity required to maintain gains in the future. Here, we present genomicSimulation, a fast and flexible tool for the stochastic simulation of crossing and selection based on real genotypes. It is fully written in C for high execution speeds, has minimal dependencies, and is available as an R package for the integration with R’s broad range of analysis and visualization tools. Comparisons of a simulated recreation of a breeding program to a real data set demonstrate the simulated offspring from the tool correctly show key population features, such as genomic relationships and approximate linkage disequilibrium patterns. Both versions of genomicSimulation are freely available on GitHub: The R package version at https://github.com/vllrs/genomicSimulation/ and the C library version at https://github.com/vllrs/genomicSimulationC/. Oxford University Press 2022-09-02 /pmc/articles/PMC9526041/ /pubmed/36053200 http://dx.doi.org/10.1093/g3journal/jkac216 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software and Data Resources
Villiers, Kira
Dinglasan, Eric
Hayes, Ben J
Voss-Fels, Kai P
genomicSimulation: fast R functions for stochastic simulation of breeding programs
title genomicSimulation: fast R functions for stochastic simulation of breeding programs
title_full genomicSimulation: fast R functions for stochastic simulation of breeding programs
title_fullStr genomicSimulation: fast R functions for stochastic simulation of breeding programs
title_full_unstemmed genomicSimulation: fast R functions for stochastic simulation of breeding programs
title_short genomicSimulation: fast R functions for stochastic simulation of breeding programs
title_sort genomicsimulation: fast r functions for stochastic simulation of breeding programs
topic Software and Data Resources
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526041/
https://www.ncbi.nlm.nih.gov/pubmed/36053200
http://dx.doi.org/10.1093/g3journal/jkac216
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