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genomicSimulation: fast R functions for stochastic simulation of breeding programs
Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity req...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526041/ https://www.ncbi.nlm.nih.gov/pubmed/36053200 http://dx.doi.org/10.1093/g3journal/jkac216 |
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author | Villiers, Kira Dinglasan, Eric Hayes, Ben J Voss-Fels, Kai P |
author_facet | Villiers, Kira Dinglasan, Eric Hayes, Ben J Voss-Fels, Kai P |
author_sort | Villiers, Kira |
collection | PubMed |
description | Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity required to maintain gains in the future. Here, we present genomicSimulation, a fast and flexible tool for the stochastic simulation of crossing and selection based on real genotypes. It is fully written in C for high execution speeds, has minimal dependencies, and is available as an R package for the integration with R’s broad range of analysis and visualization tools. Comparisons of a simulated recreation of a breeding program to a real data set demonstrate the simulated offspring from the tool correctly show key population features, such as genomic relationships and approximate linkage disequilibrium patterns. Both versions of genomicSimulation are freely available on GitHub: The R package version at https://github.com/vllrs/genomicSimulation/ and the C library version at https://github.com/vllrs/genomicSimulationC/. |
format | Online Article Text |
id | pubmed-9526041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95260412022-10-03 genomicSimulation: fast R functions for stochastic simulation of breeding programs Villiers, Kira Dinglasan, Eric Hayes, Ben J Voss-Fels, Kai P G3 (Bethesda) Software and Data Resources Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity required to maintain gains in the future. Here, we present genomicSimulation, a fast and flexible tool for the stochastic simulation of crossing and selection based on real genotypes. It is fully written in C for high execution speeds, has minimal dependencies, and is available as an R package for the integration with R’s broad range of analysis and visualization tools. Comparisons of a simulated recreation of a breeding program to a real data set demonstrate the simulated offspring from the tool correctly show key population features, such as genomic relationships and approximate linkage disequilibrium patterns. Both versions of genomicSimulation are freely available on GitHub: The R package version at https://github.com/vllrs/genomicSimulation/ and the C library version at https://github.com/vllrs/genomicSimulationC/. Oxford University Press 2022-09-02 /pmc/articles/PMC9526041/ /pubmed/36053200 http://dx.doi.org/10.1093/g3journal/jkac216 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Software and Data Resources Villiers, Kira Dinglasan, Eric Hayes, Ben J Voss-Fels, Kai P genomicSimulation: fast R functions for stochastic simulation of breeding programs |
title | genomicSimulation: fast R functions for stochastic simulation of breeding programs |
title_full | genomicSimulation: fast R functions for stochastic simulation of breeding programs |
title_fullStr | genomicSimulation: fast R functions for stochastic simulation of breeding programs |
title_full_unstemmed | genomicSimulation: fast R functions for stochastic simulation of breeding programs |
title_short | genomicSimulation: fast R functions for stochastic simulation of breeding programs |
title_sort | genomicsimulation: fast r functions for stochastic simulation of breeding programs |
topic | Software and Data Resources |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526041/ https://www.ncbi.nlm.nih.gov/pubmed/36053200 http://dx.doi.org/10.1093/g3journal/jkac216 |
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