PCSK9 is minimally associated with HDL but impairs the anti-atherosclerotic HDL effects on endothelial cell activation

Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) regulates the cell-surface localization of LDL receptors in hepatocytes and is associated with LDL and lipoprotein(a) [Lp(a)] uptake, reducing blood concentrations. However, the connection between PCSK9 and HDL is unclear. Here, we investigated t...

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Detalles Bibliográficos
Autores principales: Dafnis, Ioannis, Tsouka, Aikaterini N., Gkolfinopoulou, Christina, Tellis, Constantinos C., Chroni, Angeliki, Tselepis, Alexandros D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526147/
https://www.ncbi.nlm.nih.gov/pubmed/36067830
http://dx.doi.org/10.1016/j.jlr.2022.100272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526147/
https://www.ncbi.nlm.nih.gov/pubmed/36067830
http://dx.doi.org/10.1016/j.jlr.2022.100272

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