G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

Recent studies identified a missense mutation in the gene coding for G protein–coupled receptor kinase 6 (GRK6) that segregates with type 2 diabetes (T2D). To better understand how GRK6 might be involved in T2D, we used pharmacological inhibition and genetic knockdown in the mouse β-cell line, MIN6,...

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Detalles Bibliográficos
Autores principales: Varney, Matthew J., Steyaert, Wouter, Coucke, Paul J., Delanghe, Joris R., Uehling, David E., Joseph, Babu, Marcellus, Richard, Al-awar, Rima, Benovic, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526158/
https://www.ncbi.nlm.nih.gov/pubmed/36030052
http://dx.doi.org/10.1016/j.jbc.2022.102421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526158/
https://www.ncbi.nlm.nih.gov/pubmed/36030052
http://dx.doi.org/10.1016/j.jbc.2022.102421

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