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Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia

Transcriptional dysregulation is a prominent feature in leukemia. Here, we systematically surveyed transcription factor (TF) vulnerabilities in leukemia and uncovered TF clusters that exhibit context-specific vulnerabilities within and between different subtypes of leukemia. Among these TF clusters,...

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Detalles Bibliográficos
Autores principales:	Pingul, Bianca Y., Huang, Hua, Chen, Qingzhou, Alikarami, Fatemeh, Zhang, Zhen, Qi, Jun, Bernt, Kathrin M., Berger, Shelley L., Cao, Zhendong, Shi, Junwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526175/ https://www.ncbi.nlm.nih.gov/pubmed/36193052 http://dx.doi.org/10.1016/j.isci.2022.105139

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