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NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis
Carotid artery stenosis (CAS) develops from atherosclerotic lesions and plaques. Plaque rupture or stenosis may result in occlusion of the carotid artery. Accordingly, the asymptomatic disease becomes symptomatic, characterized by ischemic stroke or transient ischemic attacks, indicating an urgent n...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526188/ https://www.ncbi.nlm.nih.gov/pubmed/36182808 http://dx.doi.org/10.1016/j.redox.2022.102473 |
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author | Hofmann, Anja Frank, Frieda Wolk, Steffen Busch, Albert Klimova, Anna Sabarstinski, Pamela Gerlach, Michael Egorov, Dmitry Kopaliani, Irakli Weinert, Sönke Hamann, Bianca Poitz, David M. Brunssen, Coy Morawietz, Henning Schröder, Katrin Reeps, Christian |
author_facet | Hofmann, Anja Frank, Frieda Wolk, Steffen Busch, Albert Klimova, Anna Sabarstinski, Pamela Gerlach, Michael Egorov, Dmitry Kopaliani, Irakli Weinert, Sönke Hamann, Bianca Poitz, David M. Brunssen, Coy Morawietz, Henning Schröder, Katrin Reeps, Christian |
author_sort | Hofmann, Anja |
collection | PubMed |
description | Carotid artery stenosis (CAS) develops from atherosclerotic lesions and plaques. Plaque rupture or stenosis may result in occlusion of the carotid artery. Accordingly, the asymptomatic disease becomes symptomatic, characterized by ischemic stroke or transient ischemic attacks, indicating an urgent need for better understanding of the underlying molecular mechanisms and eventually prevent symptomatic CAS. NOX4, a member of the NADPH oxidase family, has anti-atherosclerotic and anti-inflammatory properties in animal models of early atherosclerosis. We hypothesized that NOX4 mRNA expression is linked to protective mechanisms in CAS patients with advanced atherosclerotic lesions as well. Indeed, NOX4 mRNA expression is lower in patients with symptomatic CAS. A low NOX4 mRNA expression is associated with an increased risk of the development of clinical symptoms. In fact, NOX4 appears to be linked to plaque stability, apoptosis and plaque hemorrhage. This is supported by cleaved caspase-3 and glycophorin C and correlates inversely with plaque NOX4 mRNA expression. Even healing of a ruptured plaque appears to be connected to NOX4, as NOX4 mRNA expression correlates to fibrous cap collagen and is reciprocally related to MMP9 activity. In conclusion, low intra-plaque NOX4 mRNA expression is associated with an increased risk for symptomatic outcome and with reduced plaque stabilizing mechanisms suggesting protective effects of NOX4 in human advanced atherosclerosis. |
format | Online Article Text |
id | pubmed-9526188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-95261882022-10-02 NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis Hofmann, Anja Frank, Frieda Wolk, Steffen Busch, Albert Klimova, Anna Sabarstinski, Pamela Gerlach, Michael Egorov, Dmitry Kopaliani, Irakli Weinert, Sönke Hamann, Bianca Poitz, David M. Brunssen, Coy Morawietz, Henning Schröder, Katrin Reeps, Christian Redox Biol Research Paper Carotid artery stenosis (CAS) develops from atherosclerotic lesions and plaques. Plaque rupture or stenosis may result in occlusion of the carotid artery. Accordingly, the asymptomatic disease becomes symptomatic, characterized by ischemic stroke or transient ischemic attacks, indicating an urgent need for better understanding of the underlying molecular mechanisms and eventually prevent symptomatic CAS. NOX4, a member of the NADPH oxidase family, has anti-atherosclerotic and anti-inflammatory properties in animal models of early atherosclerosis. We hypothesized that NOX4 mRNA expression is linked to protective mechanisms in CAS patients with advanced atherosclerotic lesions as well. Indeed, NOX4 mRNA expression is lower in patients with symptomatic CAS. A low NOX4 mRNA expression is associated with an increased risk of the development of clinical symptoms. In fact, NOX4 appears to be linked to plaque stability, apoptosis and plaque hemorrhage. This is supported by cleaved caspase-3 and glycophorin C and correlates inversely with plaque NOX4 mRNA expression. Even healing of a ruptured plaque appears to be connected to NOX4, as NOX4 mRNA expression correlates to fibrous cap collagen and is reciprocally related to MMP9 activity. In conclusion, low intra-plaque NOX4 mRNA expression is associated with an increased risk for symptomatic outcome and with reduced plaque stabilizing mechanisms suggesting protective effects of NOX4 in human advanced atherosclerosis. Elsevier 2022-09-26 /pmc/articles/PMC9526188/ /pubmed/36182808 http://dx.doi.org/10.1016/j.redox.2022.102473 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Hofmann, Anja Frank, Frieda Wolk, Steffen Busch, Albert Klimova, Anna Sabarstinski, Pamela Gerlach, Michael Egorov, Dmitry Kopaliani, Irakli Weinert, Sönke Hamann, Bianca Poitz, David M. Brunssen, Coy Morawietz, Henning Schröder, Katrin Reeps, Christian NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis |
title | NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis |
title_full | NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis |
title_fullStr | NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis |
title_full_unstemmed | NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis |
title_short | NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis |
title_sort | nox4 mrna correlates with plaque stability in patients with carotid artery stenosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526188/ https://www.ncbi.nlm.nih.gov/pubmed/36182808 http://dx.doi.org/10.1016/j.redox.2022.102473 |
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