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RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model

PURPOSE: This study aimed to explore whether RO4929097 (RO), a specific γ-secretase inhibitor, could inhibit the subretinal fibrosis in laser-induced mouse model and the relevant molecular mechanisms. METHODS: Male C57BL/6J mice were used to produce choroidal neovascularization (CNV) and subretinal...

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Detalles Bibliográficos
Autores principales:	Zhang, Chaoyang, Qin, Shiyue, Xie, Hai, Qiu, Qinghua, Wang, Haiyan, Zhang, Jingting, Luo, Dawei, Zhang, Jingfa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526367/ https://www.ncbi.nlm.nih.gov/pubmed/36155746 http://dx.doi.org/10.1167/iovs.63.10.14

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