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Optimization of an adenovirus-vectored zoster vaccine production process with chemically defined medium and a perfusion system

OBJECTIVES: Cells grown in chemically defined medium are sensitive to shear force, potentially resulting in decreased cell growth. We optimized the perfusion process for HEK293 cell-based recombinant adenovirus-vectored zoster vaccine (Ad-HER) production with chemically defined medium. METHODS: We f...

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Detalles Bibliográficos
Autores principales:	Nie, Jianqi, Sun, Yang, Ren, He, Huang, Lingling, Feng, Kai, Li, Ye, Bai, Zhonghu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526465/ https://www.ncbi.nlm.nih.gov/pubmed/36183022 http://dx.doi.org/10.1007/s10529-022-03302-6

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