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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC

BACKGROUND: Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase. Here we describe a new inhaled soluble guanylate...

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Detalles Bibliográficos
Autores principales:	Becker-Pelster, Eva M., Hahn, Michael G., Delbeck, Martina, Dietz, Lisa, Hüser, Jörg, Kopf, Johannes, Kraemer, Thomas, Marquardt, Tobias, Mondritzki, Thomas, Nagelschmitz, Johannes, Nikkho, Sylvia M., Pires, Philippe V., Tinel, Hanna, Weimann, Gerrit, Wunder, Frank, Sandner, Peter, Schuhmacher, Joachim, Stasch, Johannes-Peter, Truebel, Hubert K. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526466/ https://www.ncbi.nlm.nih.gov/pubmed/36183104 http://dx.doi.org/10.1186/s12931-022-02189-1

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