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An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma (iCCA) is a rare and aggressive malignancy that arises from the intrahepatic biliary tree and is associated with a poor prognosis. Until recently, the treatment landscape of advanced/metastatic iCCA has been limited primarily to chemotherapy. In recent years, the adve...

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Autores principales: Madoff, David C, Abi-Jaoudeh, Nadine, Braxton, David, Goyal, Lipika, Jain, Dhanpat, Odisio, Bruno C, Salem, Riad, Schattner, Mark, Sheth, Rahul, Li, Daneng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526481/
https://www.ncbi.nlm.nih.gov/pubmed/35925597
http://dx.doi.org/10.1093/oncolo/oyac139
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author Madoff, David C
Abi-Jaoudeh, Nadine
Braxton, David
Goyal, Lipika
Jain, Dhanpat
Odisio, Bruno C
Salem, Riad
Schattner, Mark
Sheth, Rahul
Li, Daneng
author_facet Madoff, David C
Abi-Jaoudeh, Nadine
Braxton, David
Goyal, Lipika
Jain, Dhanpat
Odisio, Bruno C
Salem, Riad
Schattner, Mark
Sheth, Rahul
Li, Daneng
author_sort Madoff, David C
collection PubMed
description Intrahepatic cholangiocarcinoma (iCCA) is a rare and aggressive malignancy that arises from the intrahepatic biliary tree and is associated with a poor prognosis. Until recently, the treatment landscape of advanced/metastatic iCCA has been limited primarily to chemotherapy. In recent years, the advent of biomarker testing has identified actionable genetic alterations in 40%-50% of patients with iCCA, heralding an era of precision medicine for these patients. Biomarker testing using next-generation sequencing (NGS) has since become increasingly relevant in iCCA; however, several challenges and gaps in standard image-guided liver biopsy and processing have been identified. These include variability in tissue acquisition relating to the imaging modality used for biopsy guidance, the biopsy method used, number of passes, needle choice, specimen preparation methods, the desmoplastic nature of the tumor, as well as the lack of communication among the multidisciplinary team. Recognizing these challenges and the lack of evidence-based guidelines for biomarker testing in iCCA, a multidisciplinary team of experts including interventional oncologists, a gastroenterologist, medical oncologists, and pathologists suggest best practices for optimizing tissue collection and biomarker testing in iCCA.
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spelling pubmed-95264812022-10-03 An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma Madoff, David C Abi-Jaoudeh, Nadine Braxton, David Goyal, Lipika Jain, Dhanpat Odisio, Bruno C Salem, Riad Schattner, Mark Sheth, Rahul Li, Daneng Oncologist Hepatobiliary Intrahepatic cholangiocarcinoma (iCCA) is a rare and aggressive malignancy that arises from the intrahepatic biliary tree and is associated with a poor prognosis. Until recently, the treatment landscape of advanced/metastatic iCCA has been limited primarily to chemotherapy. In recent years, the advent of biomarker testing has identified actionable genetic alterations in 40%-50% of patients with iCCA, heralding an era of precision medicine for these patients. Biomarker testing using next-generation sequencing (NGS) has since become increasingly relevant in iCCA; however, several challenges and gaps in standard image-guided liver biopsy and processing have been identified. These include variability in tissue acquisition relating to the imaging modality used for biopsy guidance, the biopsy method used, number of passes, needle choice, specimen preparation methods, the desmoplastic nature of the tumor, as well as the lack of communication among the multidisciplinary team. Recognizing these challenges and the lack of evidence-based guidelines for biomarker testing in iCCA, a multidisciplinary team of experts including interventional oncologists, a gastroenterologist, medical oncologists, and pathologists suggest best practices for optimizing tissue collection and biomarker testing in iCCA. Oxford University Press 2022-08-04 /pmc/articles/PMC9526481/ /pubmed/35925597 http://dx.doi.org/10.1093/oncolo/oyac139 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hepatobiliary
Madoff, David C
Abi-Jaoudeh, Nadine
Braxton, David
Goyal, Lipika
Jain, Dhanpat
Odisio, Bruno C
Salem, Riad
Schattner, Mark
Sheth, Rahul
Li, Daneng
An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
title An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
title_full An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
title_fullStr An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
title_full_unstemmed An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
title_short An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
title_sort expert, multidisciplinary perspective on best practices in biomarker testing in intrahepatic cholangiocarcinoma
topic Hepatobiliary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526481/
https://www.ncbi.nlm.nih.gov/pubmed/35925597
http://dx.doi.org/10.1093/oncolo/oyac139
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