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Targeting CDK4 and 6 in Cancer Therapy: Emerging Preclinical Insights Related to Abemaciclib

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4 and 6) are approved for the treatment of subsets of patients with hormone receptor positive (HR+) breast cancer (BC). In metastatic disease, strategies involving endocrine therapy combined with CDK4 and 6 inhibitors (CDK4 and 6i) imp...

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Detalles Bibliográficos
Autores principales:	Wander, Seth A, O’Brien, Neil, Litchfield, Lacey M, O’Dea, Declan, Morato Guimaraes, Claudia, Slamon, Dennis J, Goel, Shom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Academia-Pharma Intersect
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526495/ https://www.ncbi.nlm.nih.gov/pubmed/35917168 http://dx.doi.org/10.1093/oncolo/oyac138

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