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Insulin signaling in the long-lived reproductive caste of ants

In most organisms, reproduction is correlated with shorter life span. However, the reproductive queen in eusocial insects exhibits a much longer life span than that of workers. In Harpegnathos ants, when the queen dies, workers can undergo an adult caste switch to reproductive pseudo-queens (gamerga...

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Autores principales: Yan, Hua, Opachaloemphan, Comzit, Carmona-Aldana, Francisco, Mancini, Giacomo, Mlejnek, Jakub, Descostes, Nicolas, Sieriebriennikov, Bogdan, Leibholz, Alexandra, Zhou, Xiaofan, Ding, Long, Traficante, Maria, Desplan, Claude, Reinberg, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526546/
https://www.ncbi.nlm.nih.gov/pubmed/36048960
http://dx.doi.org/10.1126/science.abm8767
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author Yan, Hua
Opachaloemphan, Comzit
Carmona-Aldana, Francisco
Mancini, Giacomo
Mlejnek, Jakub
Descostes, Nicolas
Sieriebriennikov, Bogdan
Leibholz, Alexandra
Zhou, Xiaofan
Ding, Long
Traficante, Maria
Desplan, Claude
Reinberg, Danny
author_facet Yan, Hua
Opachaloemphan, Comzit
Carmona-Aldana, Francisco
Mancini, Giacomo
Mlejnek, Jakub
Descostes, Nicolas
Sieriebriennikov, Bogdan
Leibholz, Alexandra
Zhou, Xiaofan
Ding, Long
Traficante, Maria
Desplan, Claude
Reinberg, Danny
author_sort Yan, Hua
collection PubMed
description In most organisms, reproduction is correlated with shorter life span. However, the reproductive queen in eusocial insects exhibits a much longer life span than that of workers. In Harpegnathos ants, when the queen dies, workers can undergo an adult caste switch to reproductive pseudo-queens (gamergates), exhibiting a five-times prolonged life span. To explore the relation between reproduction and longevity, we compared gene expression during caste switching. Insulin expression is increased in the gamergate brain that correlates with increased lipid synthesis and production of vitellogenin in the fat body, both transported to the egg. This results from activation of the mitogen-activated protein kinase (MAPK) branch of the insulin signaling pathway. By contrast, the production in the gamergate developing ovary of anti-insulin Imp-L2 leads to decreased signaling of the AKT/forkhead box O (FOXO) branch in the fat body, which is consistent with their extended longevity.
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spelling pubmed-95265462022-10-01 Insulin signaling in the long-lived reproductive caste of ants Yan, Hua Opachaloemphan, Comzit Carmona-Aldana, Francisco Mancini, Giacomo Mlejnek, Jakub Descostes, Nicolas Sieriebriennikov, Bogdan Leibholz, Alexandra Zhou, Xiaofan Ding, Long Traficante, Maria Desplan, Claude Reinberg, Danny Science Article In most organisms, reproduction is correlated with shorter life span. However, the reproductive queen in eusocial insects exhibits a much longer life span than that of workers. In Harpegnathos ants, when the queen dies, workers can undergo an adult caste switch to reproductive pseudo-queens (gamergates), exhibiting a five-times prolonged life span. To explore the relation between reproduction and longevity, we compared gene expression during caste switching. Insulin expression is increased in the gamergate brain that correlates with increased lipid synthesis and production of vitellogenin in the fat body, both transported to the egg. This results from activation of the mitogen-activated protein kinase (MAPK) branch of the insulin signaling pathway. By contrast, the production in the gamergate developing ovary of anti-insulin Imp-L2 leads to decreased signaling of the AKT/forkhead box O (FOXO) branch in the fat body, which is consistent with their extended longevity. 2022-09-02 2022-09-01 /pmc/articles/PMC9526546/ /pubmed/36048960 http://dx.doi.org/10.1126/science.abm8767 Text en Permissions https://www.science.org/help/reprints-and-permissions https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Yan, Hua
Opachaloemphan, Comzit
Carmona-Aldana, Francisco
Mancini, Giacomo
Mlejnek, Jakub
Descostes, Nicolas
Sieriebriennikov, Bogdan
Leibholz, Alexandra
Zhou, Xiaofan
Ding, Long
Traficante, Maria
Desplan, Claude
Reinberg, Danny
Insulin signaling in the long-lived reproductive caste of ants
title Insulin signaling in the long-lived reproductive caste of ants
title_full Insulin signaling in the long-lived reproductive caste of ants
title_fullStr Insulin signaling in the long-lived reproductive caste of ants
title_full_unstemmed Insulin signaling in the long-lived reproductive caste of ants
title_short Insulin signaling in the long-lived reproductive caste of ants
title_sort insulin signaling in the long-lived reproductive caste of ants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526546/
https://www.ncbi.nlm.nih.gov/pubmed/36048960
http://dx.doi.org/10.1126/science.abm8767
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