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Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis

OBJECTIVE: The presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung aden...

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Autores principales: Bertoglio, Pietro, Aprile, Vittorio, Ventura, Luigi, Cattoni, Maria, Nachira, Dania, Lococo, Filippo, Perez, Maria Rodriguez, Guerrera, Francesco, Minervini, Fabrizio, Querzoli, Giulia, Bocchialini, Giovanni, Bacchin, Diana, Franzi, Francesca, Rindi, Guido, Bellafiore, Salvatore, Femia, Federico, Bogina, Giuseppe Salvatore, Solli, Piergiorgio, Kestenholz, Peter, Ruffini, Enrico, Paci, Massimiliano, Margaritora, Stefano, Imperatori, Andrea Selenito, Lucchi, Marco, Gnetti, Letizia, Terzi, Alberto Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526683/
https://www.ncbi.nlm.nih.gov/pubmed/35988096
http://dx.doi.org/10.1007/s00408-022-00561-y
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author Bertoglio, Pietro
Aprile, Vittorio
Ventura, Luigi
Cattoni, Maria
Nachira, Dania
Lococo, Filippo
Perez, Maria Rodriguez
Guerrera, Francesco
Minervini, Fabrizio
Querzoli, Giulia
Bocchialini, Giovanni
Bacchin, Diana
Franzi, Francesca
Rindi, Guido
Bellafiore, Salvatore
Femia, Federico
Bogina, Giuseppe Salvatore
Solli, Piergiorgio
Kestenholz, Peter
Ruffini, Enrico
Paci, Massimiliano
Margaritora, Stefano
Imperatori, Andrea Selenito
Lucchi, Marco
Gnetti, Letizia
Terzi, Alberto Claudio
author_facet Bertoglio, Pietro
Aprile, Vittorio
Ventura, Luigi
Cattoni, Maria
Nachira, Dania
Lococo, Filippo
Perez, Maria Rodriguez
Guerrera, Francesco
Minervini, Fabrizio
Querzoli, Giulia
Bocchialini, Giovanni
Bacchin, Diana
Franzi, Francesca
Rindi, Guido
Bellafiore, Salvatore
Femia, Federico
Bogina, Giuseppe Salvatore
Solli, Piergiorgio
Kestenholz, Peter
Ruffini, Enrico
Paci, Massimiliano
Margaritora, Stefano
Imperatori, Andrea Selenito
Lucchi, Marco
Gnetti, Letizia
Terzi, Alberto Claudio
author_sort Bertoglio, Pietro
collection PubMed
description OBJECTIVE: The presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas. METHODS: We retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph-node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns. RESULTS: Among 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p = 0.020), but the latter had similar OS compared to T2a (p = 0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p = 0.034), and it was similar to T2a (p = 0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p = 0.024; HR 1.285 95% CI 1.033–1.599) and DFS (p = 0.003; HR 1.196, 95% CI 1.054–1.344, respectively). These results were confirmed after the propensity score matching analysis. CONCLUSIONS: pT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors.
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spelling pubmed-95266832022-10-03 Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis Bertoglio, Pietro Aprile, Vittorio Ventura, Luigi Cattoni, Maria Nachira, Dania Lococo, Filippo Perez, Maria Rodriguez Guerrera, Francesco Minervini, Fabrizio Querzoli, Giulia Bocchialini, Giovanni Bacchin, Diana Franzi, Francesca Rindi, Guido Bellafiore, Salvatore Femia, Federico Bogina, Giuseppe Salvatore Solli, Piergiorgio Kestenholz, Peter Ruffini, Enrico Paci, Massimiliano Margaritora, Stefano Imperatori, Andrea Selenito Lucchi, Marco Gnetti, Letizia Terzi, Alberto Claudio Lung Lung Cancer OBJECTIVE: The presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas. METHODS: We retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph-node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns. RESULTS: Among 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p = 0.020), but the latter had similar OS compared to T2a (p = 0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p = 0.034), and it was similar to T2a (p = 0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p = 0.024; HR 1.285 95% CI 1.033–1.599) and DFS (p = 0.003; HR 1.196, 95% CI 1.054–1.344, respectively). These results were confirmed after the propensity score matching analysis. CONCLUSIONS: pT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors. Springer US 2022-08-21 2022 /pmc/articles/PMC9526683/ /pubmed/35988096 http://dx.doi.org/10.1007/s00408-022-00561-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Lung Cancer
Bertoglio, Pietro
Aprile, Vittorio
Ventura, Luigi
Cattoni, Maria
Nachira, Dania
Lococo, Filippo
Perez, Maria Rodriguez
Guerrera, Francesco
Minervini, Fabrizio
Querzoli, Giulia
Bocchialini, Giovanni
Bacchin, Diana
Franzi, Francesca
Rindi, Guido
Bellafiore, Salvatore
Femia, Federico
Bogina, Giuseppe Salvatore
Solli, Piergiorgio
Kestenholz, Peter
Ruffini, Enrico
Paci, Massimiliano
Margaritora, Stefano
Imperatori, Andrea Selenito
Lucchi, Marco
Gnetti, Letizia
Terzi, Alberto Claudio
Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
title Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
title_full Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
title_fullStr Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
title_full_unstemmed Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
title_short Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
title_sort impact of high-grade patterns in early-stage lung adenocarcinoma: a multicentric analysis
topic Lung Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526683/
https://www.ncbi.nlm.nih.gov/pubmed/35988096
http://dx.doi.org/10.1007/s00408-022-00561-y
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