Cell-specific regulation of gene expression using splicing-dependent frameshifting

Precise and reliable cell-specific gene delivery remains technically challenging. Here we report a splicing-based approach for controlling gene expression whereby separate translational reading frames are coupled to the inclusion or exclusion of mutated, frameshifting cell-specific alternative exons...

Descripción completa

Detalles Bibliográficos
Autores principales: Ling, Jonathan P., Bygrave, Alexei M., Santiago, Clayton P., Carmen-Orozco, Rogger P., Trinh, Vickie T., Yu, Minzhong, Li, Yini, Liu, Ying, Bowden, Kyra D., Duncan, Leighton H., Han, Jeong, Taneja, Kamil, Dongmo, Rochinelle, Babola, Travis A., Parker, Patrick, Jiang, Lizhi, Leavey, Patrick J., Smith, Jennifer J., Vistein, Rachel, Gimmen, Megan Y., Dubner, Benjamin, Helmenstine, Eric, Teodorescu, Patric, Karantanos, Theodoros, Ghiaur, Gabriel, Kanold, Patrick O., Bergles, Dwight, Langmead, Ben, Sun, Shuying, Nielsen, Kristina J., Peachey, Neal, Singh, Mandeep S., Dalton, W. Brian, Rajaii, Fatemeh, Huganir, Richard L., Blackshaw, Seth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526712/
https://www.ncbi.nlm.nih.gov/pubmed/36182931
http://dx.doi.org/10.1038/s41467-022-33523-2

Ejemplares similares

Ejemplares similares